Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions

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dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorUyar, Ahmet
dc.contributor.authorOzkan, Hueseyin
dc.contributor.authorGokcek, Ishak
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorYakan, Akin
dc.date.accessioned2024-09-18T20:28:11Z
dc.date.available2024-09-18T20:28:11Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIschemia-reperfusion injury is an organ failure caused by hypoxia and reperfusion, which is closely associated with oxidative stress and inflammation. In this study, we investigated whether nobiletin had protective effects on inflammatory parameters, oxidative damage, iNOS-eNOS expressions, and histopathological structure of renal tissue in rats with renal ischemia-reperfusion injury. For this purpose, 24 rats were divided into 4 groups: group 1 (Control), group 2 (Ischemia-Reperfusion-IR), group 3 (Nobiletin-10 mg/kg p.o.), group 4 (Nobiletin + IR). The study was continued for 7 days. At the end of the study, urea (p < 0.05), creatine (p < 0.05), MDA (p < 0.001), TNF-alpha (p < 0.001), IL-1 beta (p < 0.05), and IL-6 (p < 0.001) levels increased in the IR group; however, a significant decrease occurred in group 4 (Nobiletin + IR) and it reached the control group levels. In the IR group, GSH (p < 0.01) levels, and GSH.Px (p < 0.01) and CAT (p < 0.05) activities decreased whereas they increased significantly in group 4 (Nobiletin + IR) and reached the same levels as the control group. In histopathological analyses, destruction and increased iNOS-eNOS expressions in the IR group showed a significant decrease in group 4 (Nobiletin + IR). As a result, the application of nobiletin has shown that it has protective effects by reducing kidney damage caused by IR injury.en_US
dc.description.sponsorshipHatay MKU BAP [17.M.005]en_US
dc.description.sponsorshipThis work was financially supported with project number of 17.M.005 (Hatay MKU BAP).en_US
dc.identifier.doi10.1007/s10753-019-01123-w
dc.identifier.endpage346en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid31705353en_US
dc.identifier.scopus2-s2.0-85074860283en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage336en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01123-w
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10776
dc.identifier.volume43en_US
dc.identifier.wosWOS:000495200300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia-reperfusionen_US
dc.subjectnobiletinen_US
dc.subjectiNOS-eNOSen_US
dc.subjectinflammationen_US
dc.titleNobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressionsen_US
dc.typeArticleen_US

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