The Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival in Rat Model

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridtemel, metin/0000-0002-1829-9894
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorCan, Asli
dc.contributor.authorTemel, Metin
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorMutaf, Mehmet
dc.date.accessioned2024-09-18T20:11:33Z
dc.date.available2024-09-18T20:11:33Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: In this study, the effect of coenzyme Q(10) (CQ(10)) on flap survival was investigated. Methods: FiftyWistar Albino rats were divided into 5 groups. The survival rates of the skin flaps were assessed 10 days after complete elevation of the flaps. Regions of survival and necrosis were drawn on transparent acetate sheets and scanned into a computer. Tissue samples were assessed histopathologically after staining with hematoxylin-eosin, vascular endothelial growth factor staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-Biotin Nick End-labeling staining. To evaluate the antioxidant effect of CQ(10); malondialdehyde, nitric oxide levels were measured. Results: Viable flaps area was found higher in groups 3 and 4 as compared to groups 1, 2, and 5. In terms of vascular proliferation, elevated angiogenesis was observed in pathological specimens of groups 3 and 4 as compared to groups 1, 2, and 5. Malondialdehyde levels in groups 3 and 4 were found to be significantly decreased as compared to groups 1, 2 and 5 (P < 0.05). Moreover, serum levels of CQ(10) were found significantly increased in groups 3 and 4 (P < 0.05). Conclusions: In conclusion, CQ(10) significantly improves flap viability in rat model, and the highest levels of serumCQ(10) can be obtained by oral administration.en_US
dc.identifier.doi10.1097/SAP.0000000000000504
dc.identifier.endpageE14en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue2en_US
dc.identifier.pmid25954836en_US
dc.identifier.scopus2-s2.0-84979520750en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE9en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0000000000000504
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8944
dc.identifier.volume77en_US
dc.identifier.wosWOS:000380228100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoenzyme Q(10)en_US
dc.subjectubiquinoneen_US
dc.subjectflap survivalen_US
dc.subjectantioxidant effecten_US
dc.subjectangiogenesisen_US
dc.subjectapoptosisen_US
dc.titleThe Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival in Rat Modelen_US
dc.typeArticleen_US

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