Increased mean platelet volume in patients with panic disorder

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dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorKokacya, Mehmet Hanifi
dc.contributor.authorCopoglu, Umit Sertan
dc.contributor.authorKivrak, Yuksel
dc.contributor.authorAri, Mustafa
dc.contributor.authorSahpolat, Musa
dc.contributor.authorUlutas, Kemal Turker
dc.date.accessioned2024-09-18T20:29:46Z
dc.date.available2024-09-18T20:29:46Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.en_US
dc.identifier.doi10.2147/NDT.S94147
dc.identifier.endpage2633en_US
dc.identifier.issn1178-2021
dc.identifier.pmid26508858en_US
dc.identifier.scopus2-s2.0-84944445869en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2629en_US
dc.identifier.urihttps://doi.org/10.2147/NDT.S94147
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11052
dc.identifier.volume11en_US
dc.identifier.wosWOS:000362648800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofNeuropsychiatric Disease and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmean platelet volumeen_US
dc.subjectpanic disorderen_US
dc.subjectanxietyen_US
dc.titleIncreased mean platelet volume in patients with panic disorderen_US
dc.typeArticleen_US

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