Esterified hyaluronic acid improves cartilage viability in experimental tracheal reconstruction with an auricular graft

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dc.authoridTEMIZ, ABDULKERIM/0000-0001-8789-6003
dc.authoridBozok, Sahin/0000-0002-1256-5055
dc.authoridergur, bekir/0000-0002-6448-2593
dc.contributor.authorTemiz, Abdulkerim
dc.contributor.authorKazikdas, K. Cagdas
dc.contributor.authorErgur, Bekir
dc.contributor.authorTugyan, Kazim
dc.contributor.authorBozok, Sahin
dc.contributor.authorKaya, Durdane
dc.contributor.authorGuneli, Ensari
dc.date.accessioned2024-09-18T21:03:09Z
dc.date.available2024-09-18T21:03:09Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to determine the efficacy of esterified hyaluronic acid (HYAFF) on the vitality of auricular cartilage grafts used for tracheoplasty, with respect to macroscopic and microscopic parameters. STUDY DESIGN: Prospective, controlled. SETTING: Academic research laboratory. SUBJECTS AND METHODS: The study included 14 New Zealand rabbits acquired specifically for the study. The rabbits were divided into two groups: the control group, in which free cartilage grafts were not exposed to any materials or additional procedures (n = 7), and the hyaluronic acid (HA) treatment group, in which auricular grafts and anastomosis lines were covered with HYAFF (n = 7). Free auricular cartilage grafts used for the reconstruction of experimentally created tracheal defects were anastomosed extraluminally. All the rabbits were sacrificed two months post surgery. Samples were collected and examined histopathologically. The sections were stained with hematoxylin-eosin, Masson's trichrome, and inducible nitric oxide synthase (iNOS) and examined under a light microscope. RESULTS: Fibrosis and cartilage mass significantly differed between the control and HYAFF group (P < 0.05). Immunohistochemical examination showed that more chondrocytes stained with iNOS in the control group than in the HYAFF group, according to histologists' observations. CONCLUSION: HYAFF catalyzed wound healing with less fibrous tissue formation, had chondroprotective and stimulatory effects on chondrocyte metabolism, and decreased nitric oxide production and apoptosis via improving the nourishment of free auricular cartilage grafts, subsequently preventing hypoxia and oxidative stress, particularly in the early postimplantation period. Copyright (C) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.otohns.2010.07.007
dc.identifier.endpage778en_US
dc.identifier.issn0194-5998
dc.identifier.issue6en_US
dc.identifier.pmid21109076en_US
dc.identifier.scopus2-s2.0-78649508168en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage772en_US
dc.identifier.urihttps://doi.org/10.1016/j.otohns.2010.07.007
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13275
dc.identifier.volume143en_US
dc.identifier.wosWOS:000284974400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofOtolaryngology-Head and Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaryngotracheal Reconstructionen_US
dc.subjectRabbit Modelen_US
dc.subjectNitric-Oxideen_US
dc.subjectMitomycin-Cen_US
dc.subjectStenosisen_US
dc.subjectInflammationen_US
dc.subjectImplantsen_US
dc.subjectVitaminen_US
dc.subjectMerogelen_US
dc.subjectRepairen_US
dc.titleEsterified hyaluronic acid improves cartilage viability in experimental tracheal reconstruction with an auricular graften_US
dc.typeArticleen_US

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