Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorKozan, Ramazan
dc.contributor.authorSefil, Fatih
dc.contributor.authorBagirici, Faruk
dc.date.accessioned2024-09-18T20:06:33Z
dc.date.available2024-09-18T20:06:33Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCarnosine is a compound of naturally-occurring dipeptide that synthesized by the carnosine synthetase from beta-alanine and L-histidine. Recent reports claim that carnosine plays an important role in the control of epilepsy but its involvement in anticonvulsant functions remains unknown. In this study, we investigated the effects of carnosine in a rat model of epilepsy using the intracortical penicillin injection method. Thirty minutes after penicillin injection, the doses of 125, 250, 500, 1000 mg/kg carnosine and 90 min before penicillin injection the dose of 500 mg/kg carnosine were administered intraperitoneally. The epileptiform activity was verified by electrocorticographic (ECoG) recordings. The mean spike frequency of penicillin-induced epileptiform activity was significantly decreased in all carnosine-treated rats when compared with those of penicillin-injected. The dose of 500 mg/kg for carnosine treated and pretreated rats was found to be the most effective dose in reducing the frequency of penicillin-induced epileptiform activity. There was no significant difference in the mean onset of epileptiform activity between penicillin and 500 mg/kg camosine pretreated groups. These findings indicate that carnosine has an anticonvulsant effect on penicillin-induced epilepsy in rats. Thus, our data support the hypothesis that carnosine may be a potential anticonvulsant drug for clinical therapy of epilepsy in the future. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThe Research Fund of Ondokuz Mayis Universityen_US
dc.description.sponsorshipThis study was supported by The Research Fund of Ondokuz Mayis University.en_US
dc.identifier.doi10.1016/j.brainres.2008.08.019
dc.identifier.endpage255en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid18773880en_US
dc.identifier.scopus2-s2.0-53949111149en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2008.08.019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8576
dc.identifier.volume1239en_US
dc.identifier.wosWOS:000260950000027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarnosineen_US
dc.subjectEpilepsyen_US
dc.subjectPenicillinen_US
dc.subjectECoGen_US
dc.subjectRaten_US
dc.titleAnticonvulsant effect of carnosine on penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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