Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats

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dc.authoridBUYUK, ESRA/0000-0001-7881-7414
dc.contributor.authorPinar, Neslihan
dc.contributor.authorTopaloglu, Meyli
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorBuyuk, Esra
dc.contributor.authorKaplan, Mahir
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCisplatin (CIS) is an antineoplastic agent used for treating solid organ tumors. Toxic side effects of CIS treatment include nephrotoxicity, neurotoxicity, ototoxicity, myelosuppression and hepatotoxicity. Dexpanthenol (DEX) exhibits antioxidant and anti-inflammatory effects and protective effects against free oxygen radicals. We investigated the protective effects of DEX on CIS induced nephrotoxicity. Animals were divided into four groups of 10. The control group was given saline. The DEX group was treated with DEX for 10 days. The CIS group was treated with a single dose of CIS. The DEX + CIS group was given a single dose of CIS followed by DEX for 10 days. We found increased levels of malondialdehyde (MDA), blood urea nitrogen (BUN) and creatinine, while superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and myeloperoxidase (MPO) levels were decreased in the CIS group. MDA, BUN and creatinine levels were decreased, while SOD, CAT, GPx and MPO levels were increased in the DEX + CIS group. Renal tubule damage, inflammation and histopathology scores were significantly higher in the CIS group than the control. The DEX + CIS group exhibited less renal tubule damage and inflammation, and lower histopathological assessment scores than the CIS group. Significant cortical tubule damage and interstitial inflammation were observed in the CIS group. Tubule damage was slightly less, and mild tubule dilation and less cast formation were observed in the DEX + CIS group; also, inflammation was less severe than for the CIS group. DEX may have therapeutic potential for treating CIS induced nephrotoxicity due to its antioxidant and anti-inflammatory properties.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [16692/2017]en_US
dc.description.sponsorshipOur research was supported by a grant from the Mustafa Kemal University Research Fund [16692/2017].en_US
dc.identifier.doi10.1080/10520295.2021.1890215
dc.identifier.endpage43en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid33632031en_US
dc.identifier.scopus2-s2.0-85101831730en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1890215
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8863
dc.identifier.volume97en_US
dc.identifier.wosWOS:000622217000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectdexpanthenolen_US
dc.subjectnephrotoxicityen_US
dc.subjectratsen_US
dc.titleProtective effect of dexpanthenol on cisplatin induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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