High prevalence of Staphylococcus aureus cultivation and superantigen production in patients with psoriasis

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dc.contributor.authorBalci, Didem Didar
dc.contributor.authorDuran, Nizami
dc.contributor.authorOzer, Burcin
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorYenin, Julide Zehra
dc.date.accessioned2024-09-18T20:54:22Z
dc.date.available2024-09-18T20:54:22Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the association of Staphylococcal enterotoxins (se) a through e, exfoliative toxin (et) a and b, toxin and toxic shock syndrome toxin (tst) and mecA with psoriasis. We also investigated the distribution of Staphylococcus aureus (S. aureus) in the skin and nares. Fifty consecutive patients with chronic plaque-type psoriasis and 50 sex- and age-matched healthy controls were included in this study. There was a statistical difference in cultivation of S. aureus between lesional (64%) and non-lesional skin (14%) in patients with psoriasis (p = 0.037). S. aureus was cultivated from the nares in 25 (50%) of 50 patients with psoriasis and in 17 (34%) of 50 healthy controls (p > 0.05). In psoriasis patients, 31 (96.8%) out of the 32 strains isolated from the lesional skin and 3 (42.3%) out of the 7 strains isolated from the non-lesional skin were toxigenic (p = 0.01). Isolated strains from the nares were toxigenic in 96% (24/25) for patients with psoriasis and in 41.2% (7/17) for healthy controls, respectively (p = 0.006). Patients with cultivation-positive in lesional skin had a significantly higher PASI score than patients who were cultivation-negative in lesional skin (8.28 +/- 3.97 vs. 5.89 +/- 2.98, p = 0.031). Our results confirm that S. aureus colonization and its toxigenic-strains are associated with psoriasis. According to our findings, non-classical superantigens such as methicillin resistance gene (mecA), see and etb may also be associated with psoriasis.en_US
dc.description.sponsorshipMustafa Kemal University Research Funden_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Research Fund.en_US
dc.identifier.doi10.1684/ejd.2009.0663
dc.identifier.endpage242en_US
dc.identifier.issn1167-1122
dc.identifier.issn1952-4013
dc.identifier.issue3en_US
dc.identifier.pmid19286488en_US
dc.identifier.scopus2-s2.0-66449111630en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1684/ejd.2009.0663
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11767
dc.identifier.volume19en_US
dc.identifier.wosWOS:000265752400008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Libbey Eurotext Ltden_US
dc.relation.ispartofEuropean Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectpsoriasisen_US
dc.subjectstaphylococcus aureusen_US
dc.subjectsuperantigenen_US
dc.subjecttoxinen_US
dc.titleHigh prevalence of Staphylococcus aureus cultivation and superantigen production in patients with psoriasisen_US
dc.typeArticleen_US

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