ALPORT SYNDROME: SIGNIFICANCE OF GINGIVAL BIOPSY IN THE INITIAL DIAGNOSIS AND PERIODONTAL EVALUATION AFTER RENAL TRANSPLANTATION

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dc.authoridGuzeldemir-Akcakanat, Esra/0000-0002-0204-9487
dc.authorid, ahmet/0000-0001-6274-5700
dc.contributor.authorToygar, Hilal Uslu
dc.contributor.authorToygar, Okan
dc.contributor.authorGuzeldemir, Esra
dc.contributor.authorCilasun, Ulkem
dc.contributor.authorNacar, Ahmet
dc.contributor.authorBal, Nebil
dc.date.accessioned2024-09-18T19:52:39Z
dc.date.available2024-09-18T19:52:39Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlport Syndrome (AS) is an important hereditary disorder affecting the glomerular basement membrane. Diagnosis of AS is based on the presence of hematuric nephropathy, renal failure, hearing loss, ocular abnormalities and changes in the glomerular basement membrane of the lamina densa. The aims of this case report were to show the changes in the gingival tissues in a patient with AS under therapy with cyclosporin-A after renal transplantation and to discuss the possible role of type IV collagen in gingival basal lamina as an alternative approach for the diagnosis of AS. A 20-year-old male patient with AS underwent periodontal therapy including a series of gingivectomy surgeries. Gingival samples obtained during the second surgery were examined histopathologically and by transmission electron microscopy for further pathological examination. Gingivectomy procedures have been performed every 6 months over the last 4 years. The excessive and fibrous gingival enlargements resulted in migration of the anterior teeth, but no alveolar bone loss occurred. This is the first report to demonstrate the possible changes in the gingival tissues caused by AS. It is suggested that gingival biopsy can be an initial diagnostic tool instead of renal or skin biopsies. Proper dental and periodontal care and regular visits to the dentist could provide limited gingival hyperplasia to patients with AS.en_US
dc.identifier.doi10.1590/S1678-77572009000600016
dc.identifier.endpage629en_US
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.issue6en_US
dc.identifier.pmid20027438en_US
dc.identifier.scopus2-s2.0-72549093135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1590/S1678-77572009000600016
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7580
dc.identifier.volume17en_US
dc.identifier.wosWOS:000272950100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo Fac Odontologia Bauruen_US
dc.relation.ispartofJournal of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlport syndromeen_US
dc.subjectHereditary nephritisen_US
dc.subjectGingival overgrowthen_US
dc.subjectBiopsyen_US
dc.subjectKidney transplantationen_US
dc.subjectCyclosporinen_US
dc.titleALPORT SYNDROME: SIGNIFICANCE OF GINGIVAL BIOPSY IN THE INITIAL DIAGNOSIS AND PERIODONTAL EVALUATION AFTER RENAL TRANSPLANTATIONen_US
dc.typeArticleen_US

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