Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep

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dc.authoridCoskun, Alparslan/0000-0002-2242-9647
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridYilmaz, Gokhan/0000-0001-6495-5488
dc.contributor.authorGungor, Huseyin
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorKumru, Alper Serhat
dc.contributor.authorYilmaz, Gokhan
dc.contributor.authorCoskun, Devran
dc.contributor.authorCoskun, Alparslan
dc.date.accessioned2024-09-18T20:28:06Z
dc.date.available2024-09-18T20:28:06Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15-day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters were evaluated by non-compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that V(dss )decreased and C-0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 mu g/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non-linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of >= 1 mg/kg in sheep.en_US
dc.identifier.doi10.1111/jvp.13422
dc.identifier.endpage207en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue3en_US
dc.identifier.pmid38033195en_US
dc.identifier.scopus2-s2.0-85178223399en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage202en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.13422
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10738
dc.identifier.volume47en_US
dc.identifier.wosWOS:001111260300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectincreasing doseen_US
dc.subjectmeloxicamen_US
dc.subjectpharmacokineticsen_US
dc.subjectsheepen_US
dc.titlePharmacokinetics of meloxicam following intravenous administration at different doses in sheepen_US
dc.typeArticleen_US

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