PROTECTIVE EFFECTS OF ESCIN ON HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS

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dc.contributor.authorUgras, Daban
dc.contributor.authorMustafa, Ugur
dc.contributor.authorOguzhan, Ozcan
dc.contributor.authorMehmet, Yaldiz
dc.contributor.authorSeckin, Akkucuk
dc.contributor.authorGazi, Ozbilen Orhan
dc.contributor.authorCem, Oruc
dc.date.accessioned2024-09-18T20:29:37Z
dc.date.available2024-09-18T20:29:37Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Hepatic ischemia/reperfusion (I/R) injury is a common pathology that can occur during and after vascular surgeries and organ transplantation. Although multiple agents have been used to minimize this pathology, I/R injury remains a challenging problem. In this study, we investigated the effectivity of escin on hepatic I/R injury. Materials and methods: Hepatic I/R injury was determined in rats by the clamping of the hepatic artery and portal vein for 60 minutes, followed by 60-minute reperfusion. Escin 10 mg/kg (i.p.) was administered 30 minutes prior to ischemia and 30 minutes prior to reperfusion. Liver function tests were evaluated by the assessment of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels, the radical oxygen species (ROS) were evaluated by the assessment of malondialdehyde (MDA), and the antioxidant activity was evaluated by the assessment of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) levels. Samples of liver tissues were histopathologically evaluated. Results: The results revealed that serum AST, ALT, and LDH and the MDA levels were lower both in the pre-ischemia and pre-reperfusion escin groups. The CAT and SOD levels were higher in the pre-reperfusion escin group. Histopathologic injury was lower in the rats administered with escin. Discussion: In this study, it was demonstrated that escin provides useful outcomes since it reduces ROS formation when administered prior to ischemia and removes ROS when administered prior to reperfusion.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Mustafa Kemal Universityen_US
dc.description.sponsorshipThis study was granted by Scientific Research Projects Coordination Unit of Mustafa Kemal University.en_US
dc.identifier.doi10.19193/0393-6384_2016_4_118
dc.identifier.endpage979en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84994324006en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage973en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2016_4_118
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10970
dc.identifier.volume32en_US
dc.identifier.wosWOS:000384887000018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectischemia/reperfusion injuryen_US
dc.subjectescinen_US
dc.subjectantioxidant effecten_US
dc.titlePROTECTIVE EFFECTS OF ESCIN ON HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATSen_US
dc.typeArticleen_US

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