Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

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dc.authoridOzmen, Ozlem/0000-0002-1835-1082
dc.contributor.authorKirzioglu, F. Y.
dc.contributor.authorOzmen, O.
dc.contributor.authorDogan, B.
dc.contributor.authorBulut, M. T.
dc.contributor.authorFentoglu, O.
dc.contributor.authorOzdem, M.
dc.date.accessioned2024-09-18T20:08:22Z
dc.date.available2024-09-18T20:08:22Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Objective: Nitric oxide is a free radical that is synthesized from L-arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature-induced experimental periodontitis with/without hyperlipidaemia. Material and Methods: The rats were randomly divided into seven groups: Hy (cholesterol-added diet/water administration); HyP (cholesterol-added diet/periodontitis/water administration); HyPR (cholesterol-added diet/periodontitis/rosuvastatin administration); P (standard diet/periodontitis/water administration); PR (standard diet/periodontitis/rosuvastatin administration); C (standard diet/water administration); and R (standard diet/rosuvastatin administration). Experimental periodontitis was induced with silk ligatures, and rosuvastatin/water was administered to rats by oral gavage for the last 2 weeks of the 8-week study. After the rats were killed in week 8, histomorphometric and histological analyses were performed. Immunostained iNOS(+) cells were counted in the gingival samples and the Mann-Whitney U-test was used for statistical analysis. Results: The experimental groups exhibited increases in total cholesterol and low-density lipoprotein, except for Groups C and R. The cholesterol-added diet induced ABL in Group Hy. Of the periodontitis groups, the lowest ABL was found in Group PR. While there was a significant difference in ABL between Groups P (0.82 +/- 0.15 mm) and PR (0.70 +/- 0.21 mm) receiving a standard diet (P < .05), no difference was observed between Groups HyP (0.77 +/- 0.07 mm) and HyPR (0.76 +/- 0.11 mm) receiving a cholesterol-added diet (P > .05). Rosuvastatin significantly reduced expression of iNOS in Groups PR (18.40 +/- 2.31%) and HyPR (24.00 +/- 4.83%) compared with Group P (30.90 +/- 2.42%; P < .001). However, a larger number of iNOS(+) cells was found in Group HyPR than in Group PR (P < .001). Conclusion: Administration of rosuvastatin reduced gingival iNOS expression in ligature-induced periodontitis with/without hyperlipidaemia. It also led to significant differences in ABL in rats with periodontitis, except when periodontitis was associated with hyperlipidaemia. These findings could provide an important contribution in further studies to evaluate the role of rosuvastatin as a host modulatory agent in the pathogenesis of periodontal diseases.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (Tubitak) [213S105]; Scientific Research Foundation of Suleyman Demirel University [3424-D1-13]en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (Tubitak), Grant/Award Number: 213S105; Scientific Research Foundation of Suleyman Demirel University, Grant/Award Number: 3424-D1-13en_US
dc.identifier.doi10.1111/jre.12513
dc.identifier.endpage266en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue2en_US
dc.identifier.pmid29086411en_US
dc.identifier.scopus2-s2.0-85042410130en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12513
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8800
dc.identifier.volume53en_US
dc.identifier.wosWOS:000432017600012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcholesterolen_US
dc.subjectgingivaen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectperiodontitisen_US
dc.subjectrosuvastatinen_US
dc.titleEffects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitisen_US
dc.typeArticleen_US

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