Lack of association between obstructive sleep apnea syndrome and specular microscopic features of the corneal endothelium

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dc.authoridcakmak, ayse idil/0000-0003-4377-7314
dc.contributor.authorCakmak, Ayse Idil
dc.contributor.authorDikmen, Nursel
dc.contributor.authorEren, Ela
dc.contributor.authorAtalay, Eray
dc.date.accessioned2024-09-18T20:52:49Z
dc.date.available2024-09-18T20:52:49Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of hypoxemia and hypercapnia during sleep. The aim of this study was to determine whether OSAS causes significant changes in corneal endothelium detectable by specular microscopy. Methods This prospective, cross-sectional study compared the specular microscopic features of the corneal endothelium of patients with OSAS and age-and gender-matched controls. Patients diagnosed with OSAS by polysomnography in the sleep unit were classified using apnea-hypopnea indexes into two groups as mild-moderate OSAS group and severe OSAS group. All participants were divided into three age groups: 30-45, 46-60, and > 60 years. Corneal endothelial cell density (ECD), percentage of hexagonal cells (Hex), and coefficient of variation of cell area (CV) were obtained using a non-contact specular microscope. The measurements of each group were compared statistically. Results A total of 66 patients (51.1 +/- 9.4 years) and 88 controls (49.2 +/- 10.5 years) were examined. The mild-moderate OSAS group and the severe OSAS group had no significant differences in measures of specular microscopy compared with the controls (ECD, p = 0.84; Hex, p = 0.18; CV, p = 0.41). The mean values of ECD, Hex, and CV were 2552.56 +/- 302.49 cells/mm(2), 54.13 +/- 8.13%, and 36.41 +/- 5.92, respectively, in the mild-moderate OSAS group; 2510.52 +/- 377.12 cells/mm(2), 54.85 +/- 8.68%, and 34.77 +/- 5.02, respectively, in the severe OSAS group; 2543.37 +/- 286.94 cells/mm(2), 51.89 +/- 9.09%, and 36.03 +/- 5.32, respectively, in the control group. Conclusions There were no significant differences in corneal endothelial features between patients and controls. Although OSAS causes systemic hypoxia, its effects do not appear to result in corneal endothelial alterations detectable by specular microscopy.en_US
dc.identifier.doi10.1007/s11325-020-02222-x
dc.identifier.endpage848en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue2en_US
dc.identifier.pmid33095416en_US
dc.identifier.scopus2-s2.0-85093535971en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage843en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-020-02222-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11428
dc.identifier.volume25en_US
dc.identifier.wosWOS:000583418400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectCorneal endotheliumen_US
dc.subjectSpecular microscopeen_US
dc.subjectHypoxiaen_US
dc.titleLack of association between obstructive sleep apnea syndrome and specular microscopic features of the corneal endotheliumen_US
dc.typeArticleen_US

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