Effect of lycopene administration on plasma glucose, oxidative stress and body weight in streptozotocin diabetic rats

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dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.contributor.authorDuzguner, Vesile
dc.contributor.authorKucukgul, Altug
dc.contributor.authorErdogan, Suat
dc.contributor.authorColik, Sefa
dc.contributor.authorSahin, Kazim
dc.date.accessioned2024-09-18T20:15:10Z
dc.date.available2024-09-18T20:15:10Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTo evaluate the role of lycopene, a carotenoid antioxidant, on streptozotocin (STZ)-induced diabetic rats, 12 female rats received a single intraperitonial injection of STZ at a dose of 45 mg/kg body weight of which 6 were given 10 mg/kg lycopene orally (test group) once daily for 21 days. The administration of STZ caused a significant increase in plasma glucose and decrease in body weight. The supplementation of lycopene significantly reduced diabetic plasma glucose level by 25% and prevented body weight loss starting from 14(th) day of lycopene administration. Although tissue lipid peroxidation and nitric oxide (NO) levels were unchanged, lycopene administration significantly reduced diabetes-elevated lipid peroxidation and NO in plasma. It was concluded that lycopene supplementation may be valuable for correcting hyperglycemia and preventing diabetic complications caused by lipid peroxidation and free radicals.en_US
dc.identifier.doi10.1080/09712119.2008.9706888
dc.identifier.endpage20en_US
dc.identifier.issn0971-2119
dc.identifier.issn0974-1844
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-48249149180en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1080/09712119.2008.9706888
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9484
dc.identifier.volume33en_US
dc.identifier.wosWOS:000255109100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Applied Animal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjectlipid peroxidationen_US
dc.subjectlycopeneen_US
dc.subjectSTZen_US
dc.subjectraten_US
dc.titleEffect of lycopene administration on plasma glucose, oxidative stress and body weight in streptozotocin diabetic ratsen_US
dc.typeArticleen_US

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