Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

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dc.contributor.authorYilmaz, C.
dc.contributor.authorYuca, S. A.
dc.contributor.authorYilmaz, N.
dc.contributor.authorOener, A. F.
dc.contributor.authorCaksen, H.
dc.date.accessioned2024-09-18T20:59:09Z
dc.date.available2024-09-18T20:59:09Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 - 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4(+) lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children >= 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4(+) lymphocyte count might be responsible for SSPE in younger children.en_US
dc.identifier.doi10.1177/147323000903700326
dc.identifier.endpage834en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue3en_US
dc.identifier.pmid19589266en_US
dc.identifier.scopus2-s2.0-70349240447en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage828en_US
dc.identifier.urihttps://doi.org/10.1177/147323000903700326
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12417
dc.identifier.volume37en_US
dc.identifier.wosWOS:000268692900026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSUBACUTE SCLEROSING PANENCEPHALITISen_US
dc.subjectCHILDRENen_US
dc.subjectLYMPHOCYTE SUBGROUPSen_US
dc.subjectCD4(+) LYMPHOCYTESen_US
dc.titleEvaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitisen_US
dc.typeArticleen_US

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