Evaluation of the possible effect of inspiratory muscle training on inflammation markers and oxidative stress in childhood asthma

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dc.contributor.authorGokcek, Ozden
dc.contributor.authorYurdalan, Ufuk
dc.contributor.authorTugay, Baki Umut
dc.contributor.authorEl, Cigdem
dc.contributor.authorDogan, Serdar
dc.date.accessioned2024-09-18T20:08:16Z
dc.date.available2024-09-18T20:08:16Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAirway inflammation characterized as asthma is one of the most common chronic diseases in the world. The aim of this study was to evaluate the possible effect of inspiratory muscle training on inflammation markers and oxidative stress levels in childhood asthma. A total of 105 children (age range 8-17 years), including 70 asthmatics and 35 healthy children, participated in the study. The 70 asthma patients were randomly assigned to the inspiratory muscle training (IMT) group (n = 35) and control group (n = 35), and healthy children were assigned to the healthy group (n = 35). The IMT group was treated with the threshold IMT device for 7 days/6 weeks at 30% of maximum inspiratory pressure. Respiratory muscle strength was evaluated with a mouth pressure measuring device, and respiratory function was evaluated with a spirometer. In addition, CRP, periostin, TGF-beta, and oxidative stress levels were analyzed. The evaluation was performed only once in the healthy group and twice (at the beginning and end of 6 weeks) in asthma patients. In the study, there were significant differences between asthma patients and the healthy group in terms of MIP and MEP values, respiratory function, oxidative stress level, periostin, and TGF-beta. Post-treatment, differences were observed in the oxidative stress level, periostin, and TGF-beta of the IMT group (p <.05). Conclusion: After 6 weeks of training, IMT positively contributed to reducing the inflammation level and oxidative stress. This suggests that IMT should be used as an alternative therapy to reduce inflammation and oxidative stress.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Project [19. M. 034]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Scientific Research Project (Project number 19. M. 034).en_US
dc.identifier.doi10.1007/s00431-023-05047-4
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.pmid37285069en_US
dc.identifier.scopus2-s2.0-85161288913en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-023-05047-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8749
dc.identifier.wosWOS:001004109200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildren asthmaen_US
dc.subjectInflammationen_US
dc.subjectInspiratory muscle trainingen_US
dc.subjectOxidative stressen_US
dc.titleEvaluation of the possible effect of inspiratory muscle training on inflammation markers and oxidative stress in childhood asthmaen_US
dc.typeArticleen_US

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