Increased Epicardial Fat Tissue Is a Marker of Subclinic Atherosclerosis in Ankylosing Spondylitis

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dc.contributor.authorUstun, Nilgun
dc.contributor.authorKurt, Mustafa
dc.contributor.authorAtci, Nesrin
dc.contributor.authorYagiz, Erman
dc.contributor.authorGuler, Hayal
dc.contributor.authorTurhanoglu, Ayse
dc.date.accessioned2024-09-18T19:54:24Z
dc.date.available2024-09-18T19:54:24Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: This study aims to assess subclinical atherosclerosis markers such as epicardial fat thickness, carotid intima media thickness (CIMT), and aortic stiffness index (ASI) in ankylosing spondylitis (AS) patients as well as to investigate the relationship between the subclinical atherosclerosis markers and disease activity/function/mobility indices. Patients and methods: Twenty-six AS patients (22 males, 4 females; mean age 43 years) and 26 age-and sex-matched healthy controls (21 males, 5 females; mean age 43 years) were included. Patients and controls with any reported cardiovascular disease or other comorbidities were excluded. Disease activity, functional capacity and spinal mobility were measured using the Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, and Bath Ankylosing Spondylitis Metrology Index, respectively. All patients underwent complete transthoracic echocardiographic examination including epicardial fat thickness and ASI, and sonographic examination including CIMT. Results: There were no significant differences in demographical and cardiovascular characteristics between AS patients and healthy controls (p>0.05). Epicardial fat thickness (5.15 +/- 1.13 vs. 4.11 +/- 1.22; p=0.003), CIMT (0.70 +/- 0.16 vs. 0.60 +/- 0.10; p=0.012) and ASI (14.2 +/- 10.8 vs. 8.6 +/- 3.1; p=0.018) were significantly increased in patients with AS compared to the healthy controls. There was no significant correlation between the subclinical atherosclerosis markers and disease activity/function/mobility indices (p>0.05). Conclusion: A significantly increased epicardial fat thickness, CIMT, and ASI were observed in AS patients compared with healthy controls.en_US
dc.identifier.doi10.5606/ArchRheumatol.2014.4606
dc.identifier.endpage272en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84919354163en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2014.4606
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7711
dc.identifier.volume29en_US
dc.identifier.wosWOS:000348283200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectatherosclerosisen_US
dc.subjectepicardial fat tissueen_US
dc.titleIncreased Epicardial Fat Tissue Is a Marker of Subclinic Atherosclerosis in Ankylosing Spondylitisen_US
dc.typeArticleen_US

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