Determination of Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid Levels with Different Stages of Chronic Kidney Disease

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dc.contributor.authorErdal, Huseyin
dc.contributor.authorSungur, Sana
dc.contributor.authorKoroglu, Muaz
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-09-18T21:06:40Z
dc.date.available2024-09-18T21:06:40Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) levels in patients with different stages of chronic kidney disease (CKD). Sixty-one CKD stage 1-4 patients who applied to the nephrology outpatient clinic were recruited. A control group consisting of 26 age- and sex-matched healthy controls were also included in the study. Concentrations of PFOA and PFOS were determined by comparing their peak areas with their standard curves. All samples were analyzed three times. The average values of blank samples were subtracted from the detected PFOA and PFOS values. PFOA and PFOS levels were significantly higher in CKD group than the controls (11.4 +/- 7.47, 0.45 +/- 0.55; 0.13 +/- 0. 17, 0.19 +/- 0.4 ng/mL, respectively) (P = 0.001). Hemoglobin, serum albumin, and estimated glomerular filtration rate (eGFR) levels were significantly lower and potassium and uric acid levels were higher in the CKD group than the controls. PFOA and PFOS levels were significantly higher in all stages of CKD patients than healthy controls. However, there was no correlation between eGFR, and PFOS and PFOA. We have demonstrated significantly increased PFOA and PFOS concentrations in different stages of CKD patients. We could not find an association between eGFR, age, and serum PFOS and PFOA concentrations.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Coordination Office of Scientific Research Projects [16661]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Coordination Office of Scientific Research Projects (Project #16661).en_US
dc.identifier.doi10.4103/1319-2442.352427
dc.identifier.endpage1670en_US
dc.identifier.issn1319-2442
dc.identifier.issn2320-3838
dc.identifier.issue6en_US
dc.identifier.pmid35946279en_US
dc.identifier.scopus2-s2.0-85135725798en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1664en_US
dc.identifier.urihttps://doi.org/10.4103/1319-2442.352427
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13756
dc.identifier.volume32en_US
dc.identifier.wosWOS:000835307500016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofSaudi Journal of Kidney Diseases and Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPerfluoroalkyl Acidsen_US
dc.subjectChemicalsen_US
dc.subjectSulfonateen_US
dc.subjectHumansen_US
dc.titleDetermination of Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid Levels with Different Stages of Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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