Detection of parvovirus B19 in synovial fluids of patients with osteoarthritis

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dc.contributor.authorAslan, Bahadir
dc.contributor.authorSerin, Mehmet Sami
dc.contributor.authorAslan, Gonul
dc.contributor.authorKalacia, Aydiner
dc.contributor.authorYanat, Ahmet Nedim
dc.contributor.authorTezcan, Seda
dc.contributor.authorEmekdas, Gurol
dc.date.accessioned2024-09-18T20:53:07Z
dc.date.available2024-09-18T20:53:07Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe aimed to determine the possible role of parvovirus B19 (PVB19) in the etiology of osteoarthritis. PVB19 DNA, anti-VP1 IgM and IgG, and interleukin IL-6 levels were also assayed in synovial fluids of 42 patients with osteoarthritis and 10 controls. PVB19 DNA was detected in 28 of 42 (66.66%) in patients and in 3 of 10 (30%) in controls. IgG and IgM response were detected in 21 of 42 (50.00%) and in 2 of 42 (4.76%) patients, respectively. IL-6 were positive in 15 of 42 (36%) patients and in 3 of 10 (30%) controls. All IgG (+) samples had PVB19 DNA (100%, P < 0.001). Eleven of 15 IL-6 (+) samples had PVB19 DNA (+) (73.33%, P < 0.05). Moreover, all IL-6 (+) samples (n = 5) in stage IV had PVB19 DNA (+) (100%, P < 0.001). We have detected a significant association between the stages of osteoarthritis and PVB 19 DNA (P < 0.05). These findings support the presence of PVB 19 acting as a transactivator of IL-6 expression as reported earlier. Our results also suggest that the higher stages of osteoarthritis might be related to the increased inflammation and cell damage on joint cartilage due to PVB19. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.diagmicrobio.2007.11.003
dc.identifier.endpage385en_US
dc.identifier.issn0732-8893
dc.identifier.issue4en_US
dc.identifier.pmid18096351en_US
dc.identifier.scopus2-s2.0-40749123593en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2007.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11584
dc.identifier.volume60en_US
dc.identifier.wosWOS:000254565300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectparvovirus B19en_US
dc.subjectosteoarthritisen_US
dc.subjectIgMen_US
dc.subjectIgGen_US
dc.subjectIL-6en_US
dc.subjectPCRen_US
dc.titleDetection of parvovirus B19 in synovial fluids of patients with osteoarthritisen_US
dc.typeArticleen_US

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