Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population

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dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.authoridBayram, Suleyman/0000-0002-7087-8615
dc.authoridGenc, Ahmet/0000-0002-9826-2396
dc.contributor.authorBayram, Suleyman
dc.contributor.authorSumbul, Ahmet Taner
dc.contributor.authorBatmaci, Celal Yucel
dc.contributor.authorGenc, Ahmet
dc.date.accessioned2024-09-18T20:06:12Z
dc.date.available2024-09-18T20:06:12Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOverexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with cancer cell proliferation, invasion, progression, and metastasis as well as poor survival in a variety of human cancers including breast cancer (BC). A common functional single nucleotide polymorphism (SNP) rs920778 (T -> aEuro parts per thousand C) in the intronic enhancer of the HOTAIR has been reported to influence HOTAIR expression and cancer predisposition, but the association of HOTAIR rs920778 polymorphism with BC susceptibility and clinicopathological features has yet to be investigated. We genotyped HOTAIR rs920778 polymorphism in 245 Turkish women including 123 BC patients and 122 age-matched healthy controls by a real-time polymerase chain reaction (PCR) with the TaqMan assay. We found that the CC genotype of HOTAIR rs920778 polymorphism significantly increased the risk of BC in both codominant (odds ratio (OR) = 2.12, 95 % confidence interval (CI) 1.00-4.51, P = 0.05) and recessive (OR = 2.40, 95 % CI 1.22-4.73, P = 0.01) inheritance genetic models. Our research also indicated an association between the CC genotype of HOTAIR rs920778 polymorphism and clinicopathologic features of tumor, including advanced tumor-node-metastasis (TNM) stage, larger tumor size, distant metastasis, and poor histological grade (P < 0.05). Because our findings suggest for the first time that the CC genotype of HOTAIR rs920778 polymorphism might play important roles in genetic susceptibility to BC development and aggressiveness in a Turkish population, further independent studies are required to validate our findings in a larger series, as well as in patients of different populations.en_US
dc.identifier.doi10.1007/s13277-014-3028-0
dc.identifier.endpage3870en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue5en_US
dc.identifier.pmid25586347en_US
dc.identifier.scopus2-s2.0-84929954570en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3863en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-014-3028-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8368
dc.identifier.volume36en_US
dc.identifier.wosWOS:000355199800085en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectHOTAIRen_US
dc.subjectlncRNAen_US
dc.subjectHOTAIR rs920778 polymorphismen_US
dc.subjectGenetic susceptibilityen_US
dc.subjectClinicopathologic featuresen_US
dc.titleEffect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish populationen_US
dc.typeArticleen_US

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