Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification

Basit Öğe Kaydı
dc.contributor.authorArici, A.
dc.contributor.authorOzgur, T.
dc.contributor.authorUgras, N.
dc.contributor.authorYalcinkaya, U.
dc.date.accessioned2024-09-18T20:29:35Z
dc.date.available2024-09-18T20:29:35Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Liposarcomas are among the most common soft tissue sarcomas in adulthood. Aim: The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions. Materials and Methods: The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2. Statistical Analysis Used: Chi-Square test was applied. Results: 20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01). Conclusion: p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.en_US
dc.identifier.doi10.4103/0019-509X.118717
dc.identifier.endpage169en_US
dc.identifier.issn0019-509X
dc.identifier.issn1998-4774
dc.identifier.issue3en_US
dc.identifier.pmid24061453en_US
dc.identifier.scopus2-s2.0-84885404443en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.4103/0019-509X.118717
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10957
dc.identifier.volume50en_US
dc.identifier.wosWOS:000339909300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiposarcomaen_US
dc.subjectMDM2en_US
dc.subjectp53en_US
dc.subjectWorld health organization classificationen_US
dc.titleImmunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classificationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
776.52 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu