Effect of the N-acetylcysteine and selenium on healing of experimental maxillary sinusitis caused by Staphylococcus aureus

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dc.contributor.authorAkoglu, Ertap
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorKontas, Tunay
dc.contributor.authorDuran, Nizami
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorOnel, Suleyman Ercument
dc.contributor.authorOkuyucu, Semsettin
dc.date.accessioned2024-09-18T20:33:04Z
dc.date.available2024-09-18T20:33:04Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this controlled-randomised study was aimed to test the antioxidative effect of the N-acetylcysteine (NAC) and selenium on healing of Staphylococcus aureus sinusitis. After experimental sinusitis, 30 New Zealand rabbits were randomly divided into three groups; group A was treated with Ampicillin/sulbactam and physiological saline. Group B and C were treated with NAC and selenium in addition to Ampicillin/sulbactam, respectively. The measurements were repeated at the 3rd and 10th day. Serum malondialdehyde (MDA) levels and superoxide dismutases (SOD) activities at the 3rd day of experiment were higher than basal levels in all groups. These levels at the 10th day were lower than those of the 3rd day in groups B and C, significantly. The severity of the grade of inflammation and epithelial changes were significant between the infected and control side, but no significant change was found among the groups. S. aureus sinusitis causes to increase the level of reactive oxygen species (ROS) in the blood. These increased levels of ROS can be neutralized in some degree by antioxidative effects of NAC and selenium which are supplemented to standard antibiotic therapy. The effect of NAC and selenium on healing of maxillary sinus mucosa seems to be insignificant.en_US
dc.description.sponsorshipMustafa Kemal Universityen_US
dc.description.sponsorshipThe authors thank Dr. Cahit Ozer for his contribution to the statistical analyses of the data. This work was supported by the Research Fund of Mustafa Kemal University.en_US
dc.identifier.doi10.5897/AJMR12.087
dc.identifier.endpage2542en_US
dc.identifier.issn1996-0808
dc.identifier.issue10en_US
dc.identifier.startpage2537en_US
dc.identifier.urihttps://doi.org/10.5897/AJMR12.087
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11294
dc.identifier.volume6en_US
dc.identifier.wosWOS:000304801400041en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-acetylcysteineen_US
dc.subjectseleniumen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectsinusitisen_US
dc.subjectantioxidant effectsen_US
dc.titleEffect of the N-acetylcysteine and selenium on healing of experimental maxillary sinusitis caused by Staphylococcus aureusen_US
dc.typeArticleen_US

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