The Preventive Effect of Systemic Honokiol and Systemic Pentoxifylline on Epidural Fibrosis

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dc.contributor.authorSecinti, Kutsal Devrim
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorKurutas, Ergul Belge
dc.date.accessioned2024-09-18T20:53:03Z
dc.date.available2024-09-18T20:53:03Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: To investigate the preventive effects of systemic honokiol and pentoxifylline treatments on epidural fibrosis (EF) in the experimental laminectomy model. MATERIAL and METHODS: Thirty-two rats were divided into four equal groups. Laminectomy was performed in all rats except for the control group. One group was kept as the negative control group. Moreover, 10 mg/kg pentoxifylline and 10 mg/kg honokiol were administered intraperitoneally for 5 days, respectively, to the other two groups. The rats were sacrificed after 4 weeks. The samples were examined biochemically in terms of oxidative stress and inflammation induced by tissue damage. Histopathological and immunohistochemical investigations were also performed to detect EF severity. RESULTS: In honokiol and pentoxifylline groups compared with the negative control group, tumor necrosis factor-beta and interleukin-10 levels (indicating inflammation); myeloperoxidase, malondialdehyde, and hydroxyproline levels (indicating oxidative stress); and intercellular adhesion molecule levels (indicating fibrosis) were decreased. Histopathologically and immunohistochemically, EF was significantly reduced in the pentoxifylline and honokiol groups. Biochemical findings were consistent with the histopathological and immunohistochemical findings. CONCLUSION: Both pentoxifylline and honokiol prevent EF formation. However, this effect is more pronounced in honokiol.en_US
dc.description.sponsorshipScientific Research Projects Unit of our university [2016/6-51 M]; Turkish Neurosurgical Societyen_US
dc.description.sponsorshipThis project (2016/6-51 M) was financially supported by the Scientific Research Projects Unit of our university. Preparation for publication of this article is partly supported by Turkish Neurosurgical Society.en_US
dc.identifier.doi10.5137/1019-5149.JTN.33382-20.2
dc.identifier.endpage943en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid34664691en_US
dc.identifier.scopus2-s2.0-85120083866en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage936en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.33382-20.2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11553
dc.identifier.volume31en_US
dc.identifier.wosWOS:000726794300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjectCytokinesen_US
dc.subjectEpidural fibrosisen_US
dc.subjectHonokiolen_US
dc.subjectPentoxifyllineen_US
dc.titleThe Preventive Effect of Systemic Honokiol and Systemic Pentoxifylline on Epidural Fibrosisen_US
dc.typeArticleen_US

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