Somatostatin Receptor 1 (SSTR1) and Somatostatin Receptor 5 (SSTR5) Expressions in Hepatocellular Carcinoma

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dc.contributor.authorKoc, Ebru U.
dc.contributor.authorOzgur, Tumay
dc.contributor.authorYerci, Omer
dc.contributor.authorGurel, Selim
dc.date.accessioned2024-09-18T20:26:41Z
dc.date.available2024-09-18T20:26:41Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground/Aims: Somatostatin analogues are considered for the treatment of advanced hepatocellular carcinomas which express somatostatin receptors (SSTR). There is limited data for the SSTR subtypes. Somatostatin receptor 1 (SSTR1) and Somatostatin receptor 5 (SSTR5) expressions are investigated in needle biopsy materials of patients diagnosed as hepatocellular carcinoma, using immunohistochemical methods in the assistance of antibody kits. Methodology: The needle biopsy materials of forty-one patients that were diagnosed as hepatocellular carcinoma between 2000 and 2006 have been examined. The underlying diseases, AFP values, treatments received and the stages-of the subjects were taken under record. Biopsy sections were evaluated after SSTR1 and SSTR5 staining. Results: SSTR1 expression was found in 31 (75.6%) and SSTR5 expression in 21 of (51.2%) 41 biopsies. SSTR1 and SSTR5 expressions were not determined in 10 (24.4%) and 20 (48.8%) of the cases. In addition, no significant correlation of the SSTR1 and SSTR5 stains with the underlying diseases (chronic hepatitis and cirrhosis) and gender was observed. Conclusions: This study demonstrated that the tumor cells in the tissue samples of the patients diagnosed with advanced-stage hepatocellular carcinoma expressed a high proportion of SSTR1 and SSTR5.en_US
dc.identifier.doi10.5754/hge11662
dc.identifier.endpage1697en_US
dc.identifier.issn0172-6390
dc.identifier.issue127en_US
dc.identifier.pmid24634938en_US
dc.identifier.scopus2-s2.0-84893938004en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1693en_US
dc.identifier.urihttps://doi.org/10.5754/hge11662
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10483
dc.identifier.volume60en_US
dc.identifier.wosWOS:000330011400028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectImmunohistochemistryen_US
dc.subjectSSTR1en_US
dc.subjectSSTR5en_US
dc.titleSomatostatin Receptor 1 (SSTR1) and Somatostatin Receptor 5 (SSTR5) Expressions in Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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