High plasma nesfatin-1 level in patients with major depressive disorder

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Küçük Resim

Tarih

2011

Yazarlar

Ari, Mustafa
Ozturk, Oktay Hasan
Bez, Yasin
Oktar, Suleyman
Erduran, Dudu

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Pergamon-Elsevier Science Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Aim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r = 0.59, p<0.001) and in the control group (r = 0.58, p<0.001). Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level. (C) 2010 Elsevier Inc. All rights reserved.

Açıklama

Anahtar Kelimeler

Depression, Food intake, Major depressive disorder, Plasma nesfatin-1, Satiety

Kaynak

Progress in Neuro-Psychopharmacology & Biological Psychiatry

WoS Q Değeri

Q1

Scopus Q Değeri

Q1

Cilt

35

Sayı

2

Künye