Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide

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dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.contributor.authorOzgocmen, S
dc.contributor.authorOzyurt, H
dc.contributor.authorSogut, S
dc.contributor.authorAkyol, O
dc.date.accessioned2024-09-18T20:20:07Z
dc.date.available2024-09-18T20:20:07Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFibromyalgia (FM) is a common chronic pain syndrome with an unknown etiology. Recent years added new information to our understanding of FM pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative stress, and mechanisms of pain modulation, central sensitization, and autonomic functions in FM revealed various abnormalities indicating that multiple factors and mechanisms are involved in the pathogenesis of FM. Oxidative stress and nitric oxide may play an important role in FM pathophysiology, however it is still not clear whether oxidative stress abnormalities documented in FM are the cause or the effect. This should encourage further researches evaluating the potential role of oxidative stress and nitric oxide in the pathophysiology of FM and the efficacy of antioxidant treatments (omega-3 and -6 fatty acids, vitamins and others) in double blind and placebo controlled trials. These future researches will enhance our understanding of the complex pathophysiology of this disorder.en_US
dc.identifier.doi10.1007/s00296-005-0078-z
dc.identifier.endpage597en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue7en_US
dc.identifier.pmid16328420en_US
dc.identifier.scopus2-s2.0-33645859615en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0078-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10059
dc.identifier.volume26en_US
dc.identifier.wosWOS:000236781100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfibromyalgiaen_US
dc.subjectpathophysiologyen_US
dc.subjectoxidative stressen_US
dc.subjectnitric oxideen_US
dc.titleCurrent concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxideen_US
dc.typeReview Articleen_US

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