Seroprevalence of hepatitis B and hepatitis C in patients with thalassemia and sickle cell anemia in a long-term follow-up

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dc.contributor.authorOcak, Sabahattin
dc.contributor.authorKaya, Hasan
dc.contributor.authorCetin, Meryem
dc.contributor.authorGali, Edip
dc.contributor.authorOzturk, Muge
dc.date.accessioned2024-09-18T20:59:21Z
dc.date.available2024-09-18T20:59:21Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground. Transfusion-dependent patients are more prone to acquiring various transfusion-transmitted infections such as hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV). The aim of the study was to investigate the prevalence of these infections in patients with thalassemia and with sickle cell anemia (SCA) receiving multiple blood transfusions. Methods. The subjects of the present study were 399 multi-transfused patients with beta-thalassemia major or intermedia and SCA who have been registered at the two regional hemoglobinopathy centers in Turkey since 1996. Hepatitis B surface antigen (HBsAg), hepatitis C virus antibodies (anti-HCV) and human immunodeficiency virus antibodies (anti-HIV) tests were assayed by a second-generation enzyme-linked immunosorbent assay method. Results. Of the 399 patients, 3 were HBsAg positive (0.75%), 18 were anti-HCV positive (4.5%), and none was anti-HIV positive. All patients with HBsAg and 14 (77.7%) patients with HCV received initial blood transfusions before second-generation tests were performed. Patients who were anti-HCV positive had a significantly higher mean number of blood transfusions and peak serum alanine transaminase level than anti-HCV-negative patients. Conclusions. These results showed that after introduction of more sensitive screening tests and stringent donor selection procedures, incidence of HCV infection was significantly reduced, but there was still a serious risk for HCV infection, and there was a minor risk for HBV infection in patients with thalassemia and SCA. (C) 2006 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2006.04.007
dc.identifier.endpage898en_US
dc.identifier.issn0188-4409
dc.identifier.issue7en_US
dc.identifier.pmid16971232en_US
dc.identifier.scopus2-s2.0-33748316851en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage895en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2006.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12535
dc.identifier.volume37en_US
dc.identifier.wosWOS:000240894300015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthalassemiaen_US
dc.subjectsickle cell anemiaen_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis Cen_US
dc.subjecthuman immunodeficiency virusen_US
dc.titleSeroprevalence of hepatitis B and hepatitis C in patients with thalassemia and sickle cell anemia in a long-term follow-upen_US
dc.typeArticleen_US

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