Investigation of oxidative stress in patients with alopecia areata and its relationship with disease severity, duration, recurrence and pattern

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dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorYenin, J. Z.
dc.contributor.authorSerarslan, G.
dc.contributor.authorYoenden, Z.
dc.contributor.authorUlutas, K. T.
dc.date.accessioned2024-09-18T21:05:13Z
dc.date.available2024-09-18T21:05:13Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Alopecia areata (AA) is an inflammatory autoimmune disease that causes hair loss on the scalp or trunk without scarring. Although the precise aetiopathogenesis of alopecia areata remains unknown, oxidative stress is thought to play a role. Aim To investigate the relationship between severity and the role of oxidative stress in AA, by measuring plasma oxidant levels and antioxidant enzyme activities in erythrocytes. Methods In total, 62 patients with AA (24 males and 38 females), and 62 sex- and age-matched healthy controls (HCs) were enrolled in the study. We investigated the levels of plasma malondialdehyde (MDA) and the activities of erythrocyte catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). The relationship between oxidative stress and AA was also investigated with regard to disease pattern, severity, duration and recurrence. Results The mean erythrocyte GSH-Px and SOD activities were significantly reduced (P<0.001 and P<0.001 respectively) compared with the control group. Plasma MDA levels were increased but statistically insignificant (P=0.08) in patients with AA compared with controls. No significant difference between erythrocyte CAT activities was observed between patients and controls (P=0.2). In addition, we observed no statistically significant difference in patient plasma MDA levels or erythrocyte CAT, GSH-Px or SOD activities with regard to AA severity, duration, recurrence or pattern (P>0.05). Conclusions Patients with AA displayed reduced erythrocyte SOD and GSH-Px activities and enhanced plasma MDA levels. These findings support the possible role of oxidative stress in the pathogenesis of AA.en_US
dc.description.sponsorshipMustafa Kemal Universityen_US
dc.description.sponsorshipThis work was supported by Mustafa Kemal University.en_US
dc.identifier.doi10.1111/ced.12556
dc.identifier.endpage621en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue6en_US
dc.identifier.pmid25524272en_US
dc.identifier.scopus2-s2.0-84937639686en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1111/ced.12556
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13452
dc.identifier.volume40en_US
dc.identifier.wosWOS:000358198100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric-Oxide Levelsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFree-Radicalsen_US
dc.subjectAntioxidantsen_US
dc.subjectUpdateen_US
dc.titleInvestigation of oxidative stress in patients with alopecia areata and its relationship with disease severity, duration, recurrence and patternen_US
dc.typeArticleen_US

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