High Dose Oral Furosemide With Salt Ingestion In The Treatment Of Refractory Ascites Of Liver Cirrhosis

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dc.authorscopusid24470317500
dc.authorscopusid58602450200
dc.authorscopusid56478465500
dc.authorscopusid25641781500
dc.authorscopusid35796175800
dc.authorscopusid7004054394
dc.contributor.authorYakar, Tolga
dc.contributor.authorDemir, Mehmet
dc.contributor.authorDogan, Ozlem
dc.contributor.authorParlakgumus, Alper
dc.contributor.authorOzer, Birol
dc.contributor.authorSerin, Ender
dc.date.accessioned2024-09-19T15:49:43Z
dc.date.available2024-09-19T15:49:43Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: We aimed to evaluate and compare the efficacy and safety of high-dose furosemide+salt orally by comparing HSS+ furosemide (i.v.) and repeated paracentesis in patients with RA. Methods: This was a prospective study of 78 cirrhotic patients with RA, randomized into three groups: Group A (n= 25) i.v. furosemide (200-300 mg bid) and 3% hypotonic saline solution (HSS) (once or twice a day); Group B (n= 26) oral furosemide tablets (360-520 mg bid) and salt (2.5 g bid); and, Group C (n= 27) repeated large-volume-paracentesis (RLVP) with albumin infusion. Patients without hyperkalemia were administrated 100 mg of spironolactone/day. During the follow-up; INR, creatinine, and total bilirubin levels were measured to determine the change in MELD (model of end stage liver disease) score. Results: Hepatic encephalopathy (HE), severe episodes of spontaneous bacterial peritonitis (SBP) and pleural effusions (PE) occurred more frequently in Group C. Improvement in Child-Pugh and MELD score was better in Group A and B than Group C. In Group B, improvements were seen in the Child-Pugh and MELD score, reduction in body weight, duration and number of hospitalization. In Groups A and B, remarkable increases in diuresis were observed (706±116 to 2425±633 mL and 691±111 to 2405±772 mL) and serum sodium levels also improved. HE and SBP were occurred more often in group C (p<0.002). Hospitalization decreased significantly in Group B (p<0.001). There was no significant difference in survival among groups. Conclusion: High dose oral furosemide with salt ingestion may be an alternative, effective, safe and well-tolerated method of therapy for RA © 2016. Clinical and Investigative Medicine. All Rights Reserved.en_US
dc.identifier.doi10.25011/CIM.V39I6.27502
dc.identifier.endpage60en_US
dc.identifier.issn0147-958X
dc.identifier.issue6en_US
dc.identifier.pmid27917793en_US
dc.identifier.scopus2-s2.0-85047594085en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.25011/CIM.V39I6.27502
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15356
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThe Canadian Society for Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdministration, Oralen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAlbuminsen_US
dc.subjectAscitesen_US
dc.subjectBilirubinen_US
dc.subjectCreatinineen_US
dc.subjectEnd Stage Liver Diseaseen_US
dc.subjectFemaleen_US
dc.subjectFurosemideen_US
dc.subjectHepatic Encephalopathyen_US
dc.subjectHospitalizationen_US
dc.subjectHumansen_US
dc.subjectHyperkalemiaen_US
dc.subjectInternational Normalized Ratioen_US
dc.subjectLiver Cirrhosisen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectParacentesisen_US
dc.subjectPeritonitisen_US
dc.subjectPleural Effusionen_US
dc.subjectProspective Studiesen_US
dc.subjectSodium Chlorideen_US
dc.subjectSodium Potassium Chloride Symporter Inhibitorsen_US
dc.subjectSpironolactoneen_US
dc.subjectTreatment Outcomeen_US
dc.subjectalbuminoiden_US
dc.subjectbilirubinen_US
dc.subjectcreatinineen_US
dc.subjectfurosemideen_US
dc.subjectloop diuretic agenten_US
dc.subjectsodium chlorideen_US
dc.subjectspironolactoneen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectascitesen_US
dc.subjectblooden_US
dc.subjectchemically induceden_US
dc.subjectchemistryen_US
dc.subjectcomplicationen_US
dc.subjectcontrolled studyen_US
dc.subjectend stage liver diseaseen_US
dc.subjectfemaleen_US
dc.subjecthepatic encephalopathyen_US
dc.subjecthospitalizationen_US
dc.subjecthumanen_US
dc.subjecthyperkalemiaen_US
dc.subjectinternational normalized ratioen_US
dc.subjectliver cirrhosisen_US
dc.subjectmaleen_US
dc.subjectmicrobiologyen_US
dc.subjectmiddle ageden_US
dc.subjectoral drug administrationen_US
dc.subjectparacentesisen_US
dc.subjectperitonitisen_US
dc.subjectpleura effusionen_US
dc.subjectprospective studyen_US
dc.subjectrandomized controlled trialen_US
dc.subjecttreatment outcomeen_US
dc.subjectvery elderlyen_US
dc.titleHigh Dose Oral Furosemide With Salt Ingestion In The Treatment Of Refractory Ascites Of Liver Cirrhosisen_US
dc.typeArticleen_US

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