Investigation of Possible Ecotoxic Effects of Acrylamide on Liver with the Azaserine-Rat Model

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dc.authoridYILDIZ, Hasan/0000-0001-5486-4005
dc.contributor.authorKalipci, Erkan
dc.contributor.authorYener, Yesim
dc.contributor.authorYildiz, Hasan
dc.contributor.authorOztas, Haydar
dc.date.accessioned2024-09-18T19:50:18Z
dc.date.available2024-09-18T19:50:18Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractIn this study, when acrylamide is taken into the body by nutrition, it was aimed to investigate its ecotoxic and/or carcinogenic effects on the liver. The Azaserine-Rat model developed by Longnecker and Curphey was used in this research, and in total 60 Wistar Albino race male rats were used, including 10 rats in each group. The rats were fed for 16 weeks by adding acrylamide at rates of 5 mg/kg/day and 10 mg/kg/day in drinking water. Moreover, neoplastic structures were formed by azaserine application and its effect on the development of these neoplastic structures was also investigated. As a result of this study, it was determined that ecotoxic and histopathological alterations, together with atypical cells, focuses formed in the livers of the rats in the group to which azaserine was applied and in the livers of the rats in the groups that included 5 and 10 mg/kg/day acrylamide in their drinking water. Moreover, it was found that the development (average focus diameter and focus volume) of neoplastic structures formed with azaserine was increased by 5 and 10 mg/kg/day acrylamide. These results make it possible for the probability of acrylamide to be a cancer initiator in the livers of rats.en_US
dc.description.sponsorshipSelcuk University [09401045]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the Selcuk University Research Fund (BAP) for financially supporting this work (Project No. 09401045).en_US
dc.identifier.endpage1247en_US
dc.identifier.issn1230-1485
dc.identifier.issn2083-5906
dc.identifier.issue5en_US
dc.identifier.startpage1243en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7340
dc.identifier.volume21en_US
dc.identifier.wosWOS:000312234300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherHarden_US
dc.relation.ispartofPolish Journal of Environmental Studiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacrylamideen_US
dc.subjectACFen_US
dc.subjectcarcinogenic effectsen_US
dc.subjectquantitative analysisen_US
dc.subjectliveren_US
dc.titleInvestigation of Possible Ecotoxic Effects of Acrylamide on Liver with the Azaserine-Rat Modelen_US
dc.typeArticleen_US

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