The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary

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dc.authoridASLAN, ERDOGAN/0000-0002-9573-5688
dc.contributor.authorErgun, Yasar
dc.contributor.authorKoc, Ahmet
dc.contributor.authorDolapcioglu, Kenan
dc.contributor.authorAkaydin, Yesim
dc.contributor.authorDogruer, Gokhan
dc.contributor.authorKontas, Tunay
dc.contributor.authorKozlu, Tolunay
dc.date.accessioned2024-09-18T19:50:23Z
dc.date.available2024-09-18T19:50:23Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to investigate the effects of erythropoietin and dimethylsulfoxide in the recovery from ischemia-reperfusion injury in an experimental rat adnexal torsion model. Study design: Thirty-six Wistar-albino rats were divided into six groups. Except for the sham operation group, all groups were subjected to left unilateral adnexal torsion for 3 h. Erythropoietin and dimethylsulfoxide were intraperitoneally administered 30 min before the detorsion operation. Malondialdehyde and nitric oxide levels were detected from both the plasma and the tissue samples. The sections of the tissues were evaluated histologically. The results were analyzed by a one-way analysis of the variance (ANOVA) followed by the Duncan test for multiple comparisons using computer software, SPSS Version 15.0 for Windows. Results: This study demonstrated that dimethylsulfoxide and erythropoietin pretreatment attenuated ischemia-reperfusion-induced lipid peroxidation, prevented post-ischemic ovarian injury and helped to maintain the ovarian morphology. Malondialdehyde levels of plasma and ovary were higher in the torsion and detorsion groups than the sham group. This showed that ischemia-reperfusion had caused lipid peroxidation of the ovarian tissue, thus leading to oxidative damage. One of the major findings of this study is that malondialdehyde was significantly decreased in the plasma of rats who were pre-treated with dimethylsulfoxide and erythropoietin before detorsion. This suggests that dimethylsulfoxide and erythropoietin might prevent oxidative damage in ovarian ischemia-reperfusion injury. Histological examination confirmed that reperfusion caused more detrimental effects than only ischemia, which could be at least partially prevented by dimethylsulfoxide and erythropoietin administration prior to detorsion. Conclusion: Erythropoietin and dimethylsulfoxide may have beneficial effects in ischemia-reperfusion injury in ovarian torsion. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2010.05.025
dc.identifier.endpage190en_US
dc.identifier.issn0301-2115
dc.identifier.issue2en_US
dc.identifier.pmid20576345en_US
dc.identifier.scopus2-s2.0-77957756133en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2010.05.025
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7413
dc.identifier.volume152en_US
dc.identifier.wosWOS:000283913100014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdnexal torsionen_US
dc.subjectErythropoietinen_US
dc.subjectDimethylsulfoxideen_US
dc.subjectMicroscopyen_US
dc.subjectRaten_US
dc.titleThe protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovaryen_US
dc.typeArticleen_US

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