Effects of ?-Glucan Pretreatment on Acetylsalicylic Acid-Induced Gastric Damage: An Experimental Study in Rats

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dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authorid, ahmet/0000-0001-6274-5700
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorAydin, Mehmet
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorYetim, Ibrahim
dc.contributor.authorNacar, Ahmet
dc.contributor.authorOktar, Suleyman
dc.date.accessioned2024-09-18T20:04:24Z
dc.date.available2024-09-18T20:04:24Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: NSAIDs have been found to induce gastrointestinal tract damage. Recently, it has been suggested that this might be mediated by lipid peroxidation. OBJECTIVE: The aim of this study was to assess the potential protective effects of beta-glucan against acetylsalicylic acid (ASA)-induced gastric damage by means of its antioxidant capacity in an experimental rat model. METHODS: Thirty-two male Wistar albino rats (200-250 g) were randomized into 4 groups consisting of 8 rats each. The beta-glucan group received 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. The ASA group received saline once a day for 10 days and 300 mg/kg (20 mg/mL) ASA as a single dose, 4 hours before anesthesia. The ASA+beta-glucan group was administered 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. Additionally, 300 mg/kg (20 mg/mL) ASA was administered as a single dose, 4 hours before anesthesia. The control group received saline once a day for 10 days and 30 minutes before anesthesia. All medications were administered by intragastric gavage. The stomach from each rat was dissected and divided into 2 parts for histologic and biochemical analysis. Gastric tissue malondialdehyde (MDA), nitric oxide (NO) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were determined for oxidative parameter analysis. RESULTS: The gastroprotective and antioxidant effects of beta-glucan appeared to attenuate the ASA-induced gastric tissue damage. Compared with the control group, MDA and NO levels and CAT and GSH-Px activities were significantly increased in the stomachs of ASA-treated rats (MDA, 4.12 [0.44] to 13.41 [1.05] mu mol/L; NO, 8.04 [7.25-9.10] vs 30.35 [22.34-37.95] mu mol/g protein; CAT, 0.050 [0.004] to 0.083 [0.003] k/g protein; GSH-Px, 0.57 [0.42-0.66] to 1.55 [1.19-1.76] U/L; all, P < 0.001), whereas SOD activity was significantly decreased in the same group (291 [29] to 124 [61 U/mL; P < 0.001). In the ASA+beta-glucan group, MDA and NO levels and CAT and GSH-Px activities were found to be significantly lower, while SOD activity was found to be significantly higher, in comparison with the ASA-treated group (all, P < 0.001). CONCLUSION: beta-Glucan appeared to attenuate the gastric damage caused by ASA in these rats. (Curr Ther Res Clin Exp. 2010;71:369-383) (C) 2010 Elsevier HS Journals, Inc.en_US
dc.description.sponsorshipMustafa Kemal University [03 M 0107]en_US
dc.description.sponsorshipThis study was supported by The Research Fund of Mustafa Kemal University (No: 03 M 0107). The authors have indicated that they have no conflicts of interest regarding the content of this article.en_US
dc.identifier.doi10.1016/S0011-393X(10)80003-7
dc.identifier.endpage383en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue6en_US
dc.identifier.pmid24688156en_US
dc.identifier.scopus2-s2.0-79952084420en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.1016/S0011-393X(10)80003-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8140
dc.identifier.volume71en_US
dc.identifier.wosWOS:000286350500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbeta-glucanen_US
dc.subjectlipid peroxidationen_US
dc.subjectgastric damageen_US
dc.subjectacetylsalicylic aciden_US
dc.titleEffects of ?-Glucan Pretreatment on Acetylsalicylic Acid-Induced Gastric Damage: An Experimental Study in Ratsen_US
dc.typeArticleen_US

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