Comparison of Platelet Distribution Width and CA19-9 in Resectable Pancreas Cancer

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dc.authorscopusid55507626600
dc.authorscopusid54894407400
dc.authorscopusid6603061715
dc.contributor.authorUlutas, Kemal Turker
dc.contributor.authorSarici, Inanc Samil
dc.contributor.authorArpaci, Abdullah
dc.date.accessioned2024-09-19T15:45:23Z
dc.date.available2024-09-19T15:45:23Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Platelets are considered an important source of prothrombotic agents associated with inflammation in cancer related diseases. We aimed to compare the diagnostic accuracy of the platelet distribution width (PDW) and CA19-9 in resectable pancreas cancer. Method: A total of 83 stage-1 and 2 pancreatic adenocarcinoma (PAC) patients, and 85 age and sex-matched healthy participants were included in the study. All preoperative patient data, including PDW and CA19-9 were analyzed in terms of sensitivity, specificity, positive and negative predictive values, likelihood ratios, and diagnostic accuracy. Results: Demographic features were not significantly different among the groups. Platelet distribution width and CA19-9 were significantly higher in PAC compared to control group (p= 0.0001). Diagnostically, the sensitivity and specificity were 79% and 85% for PDW, while 78% and 91% for CA19-9. Diagnostic accuracy was measured by the area under the ROC curve, and PDW differs significantly (p<0.001), with a value of 0.874 (95% CI: 0.804-0.929). Conclusion: Platelet distribution width indicated similar sensitivity and specificity with CA19-9 in patients with resectable PAC. This result strongly advice that PDW, which has more routine option and cost-effectivity than CA19-9, can be used for diagnosis of resectable PAC as a strong alternative.en_US
dc.identifier.doi10.5455/medarh.2018.72.210-213
dc.identifier.endpage213en_US
dc.identifier.issn1986-5961
dc.identifier.issue3en_US
dc.identifier.pmid30061769en_US
dc.identifier.scopus2-s2.0-85059795073en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.5455/medarh.2018.72.210-213
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14641
dc.identifier.volume72en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofMedical archives (Sarajevo, Bosnia and Herzegovina)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCA19-9en_US
dc.subjectplatelet distribution widthen_US
dc.subjectresectable pancreas canceren_US
dc.titleComparison of Platelet Distribution Width and CA19-9 in Resectable Pancreas Canceren_US
dc.typeArticleen_US

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