The protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain

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dc.authoridEkin, Suat/0000-0002-6502-5028
dc.authoridKARAGOZOGLU, FATMA/0000-0001-7970-0306
dc.authoridAydin, Sevinc/0000-0001-8597-8064
dc.authoridbengu, aydin sukru/0000-0002-7635-4855
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorBengu, Aydin Sukru
dc.contributor.authorMelek, Sule
dc.contributor.authorKaragozoglu, Fatma
dc.contributor.authorAydin, Sevinc
dc.date.accessioned2024-09-18T20:02:37Z
dc.date.available2024-09-18T20:02:37Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate the protective effects of arbutin (ARB) against brain injury induced in rats with potassium bromate (KBrO3). The rats were divided into four groups as Group 1: Control (0.9% NaCl ml/kg/day p.), Group 2: KBrO3 (100 mg/kg (gavage), Group 3: ARB (50 mg/kg/day p.), and Group 4: KBrO3 + ARB (100 mg/kg (gavage) + 50 mg/kg/day p.). At the end of the fifth day of the study, the rats in all groups were killed, and their brain tissues were collected. In the collected brain tissues, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured, and routine histopathological examinations were made. The MDA levels in the group that was exposed to KBrO3 were significantly higher than those in the control group (p < 0.001). In comparison to the KBrO3 group, the MDA levels in the KBrO3 + ARB group were significantly lower (p < 0.001). It was observed that SOD and CAT enzyme activity levels were significantly lower in the KBrO3 group compared to the control group (p < 0.001), while these levels were significantly higher in the KBrO3 + ARB group than in the KBrO3 group (p < 0.001). Additionally, the group that was subjected to KBrO3 toxicity, as well as ARB administration, had much lower levels of histopathologic signs than the group that was subjected to KBrO3 toxicity only. Consequently, it was found that KBrO3 exposure led to injury in the brain tissues of the rats, and using ARB was effective in preventing this injury.en_US
dc.identifier.doi10.1002/jbt.23248
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue2en_US
dc.identifier.pmid36284482en_US
dc.identifier.scopus2-s2.0-85140376366en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23248
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7911
dc.identifier.volume37en_US
dc.identifier.wosWOS:000871772200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectarbutin (beta-d-glucopyranosideen_US
dc.subject4-hydroxyphenyl)en_US
dc.subjectcatalase (CAT)en_US
dc.subjectmalondialdehyde (MDA)en_US
dc.subjectpotassium bromate (KBrO3)en_US
dc.subjectsuperoxide dismutase (SOD)en_US
dc.titleThe protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brainen_US
dc.typeArticleen_US

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