The protective effects of peptide YY and ghrelin in acute biliary pancreatitis

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dc.authorscopusid8988852800
dc.authorscopusid35621697200
dc.authorscopusid25030483100
dc.authorscopusid18433701600
dc.authorscopusid34875451400
dc.authorscopusid57197568884
dc.authorscopusid54584164400
dc.contributor.authorAydogan, Akin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorAydin, Mehmet
dc.contributor.authorMotor, Sedat
dc.contributor.authorUgur, Mustafa
dc.contributor.authorOruc, Cem
dc.date.accessioned2024-09-19T15:41:24Z
dc.date.available2024-09-19T15:41:24Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Ghrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-?, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited inflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.en_US
dc.identifier.endpage327en_US
dc.identifier.issn0393-6384
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84898435914en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14239
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherActa Medica Mediterraneaen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute biliary pancreatitisen_US
dc.subjectGhrelinen_US
dc.subjectGut hormoneen_US
dc.subjectPeptide YYen_US
dc.titleThe protective effects of peptide YY and ghrelin in acute biliary pancreatitisen_US
dc.typeArticleen_US

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