Comparison of the protective effect of the upper zone of the growth plate and unique cartilage matrix-associated protein with hyaluronic acid and corticosteroids on an experimental rat osteoarthritis model

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorGokdemir, Cemil Emre
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorKalacı, Aydıner
dc.date.accessioned2024-09-18T20:13:23Z
dc.date.available2024-09-18T20:13:23Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: This study sought to compare the protective effect of the upper zone of the growth plate and unique cartilage matrix-associated protein (UCMA) with hyaluronic acid (HA) and corticosteroids (CS) in a rat model of osteoarthritis (OA). Materials and methods: In the experimental animal study, 40 adult male rats were randomly assigned into five groups: control, monosodium iodoacetate (MIA) + vehicle (MIA+V), MIA+HA, MIA+CS, and MIA+UCMA. The OA model was induced by an intra-articular MIA injection to the right knee, and intra-articular injections into the right knee were performed on the treatment groups seven times every three days for 21 days. The knee joints were taken for histopathology and immunohistochemistry (IHC) analyses after the rats were sacrificed. All sections were stained with hematoxylin-eosin, safranin O and fast green FCF, and toluidine blue, and bone morphogenetic protein 2 (BMP-2) and nuclear factor-kappa B (NF-kappa B) expressions were analyzed with IHC. The Mankin scoring was utilized to determine the histopathological changes in the joint tissues. Results: Mankin score was significantly higher in the MIA group compared to the control group. Histopathologically, in the UCMA-, HA-, and CS-treated groups, degenerations in the articular cartilage were milder than in the MIA+V group. Mankin score was found to be decreased significantly in the UCMA-, HA-, and CS-treated groups compared to the MIA group. Furthermore, IHC analyses revealed that NF-kappa B and BMP-2 expressions elevated in the MIA-induced OA model, while they were downregulated after UCMA, HA, and CS treatments. Conclusion: Our data revealed that UCMA could be used as a potential protective molecule in the prevention and treatment of OA. Furthermore, the protective effect of UCMA was similar to HA and CS, and its possible beneficial roles against OA may be linked to the reduced BMP-2 and NF-kappa B levels. Further experimental research would make significant contributions to a better understanding of the therapeutic effect of UCMA on degenerative cartilage tissues.en_US
dc.description.sponsorshipScientific Research Projects Coordinator of Hatay Mustafa Kemal University [19]en_US
dc.description.sponsorshipFunding: This study was supported by the Scientific Research Projects Coordinator of Hatay Mustafa Kemal University under project number 19.U.005.en_US
dc.identifier.doi10.46497/ArchRheumatol.2024.10066
dc.identifier.endpage88en_US
dc.identifier.issn2618-6500
dc.identifier.issue1en_US
dc.identifier.pmid38774694en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2024.10066
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9153
dc.identifier.volume39en_US
dc.identifier.wosWOS:001162473600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorticosteroiden_US
dc.subjecthyaluronic aciden_US
dc.subjectmonosodium iodoacetateen_US
dc.subjectosteoarthritisen_US
dc.subjectunique cartilage matrix-associated proteinen_US
dc.titleComparison of the protective effect of the upper zone of the growth plate and unique cartilage matrix-associated protein with hyaluronic acid and corticosteroids on an experimental rat osteoarthritis modelen_US
dc.typeArticleen_US

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