Protective effects of nobiletin on cisplatin induced neurotoxicity in rats

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dc.authoridATES, Mehmet Burak/0000-0003-1297-426X
dc.authoridOzdemir, Ozgur/0000-0002-1595-0557
dc.contributor.authorKazak, Filiz
dc.contributor.authorAkalin, Pinar Peker
dc.contributor.authorYarim, Gul Fatma
dc.contributor.authorBaspinar, Nuri
dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorAtes, Mehmet Burak
dc.contributor.authorAltug, Muhammed Enes
dc.date.accessioned2024-09-18T20:04:21Z
dc.date.available2024-09-18T20:04:21Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants and histopathology. Methods Forty male Wistar Albino rats were divided into four groups: control, cisplatin (CIS), cisplatin + nobiletin (CIS + NOB) and nobiletin + cisplatin (NOB + CIS). CIS + NOB was applied nobiletin (10 mg/kg, i.p.) during the last four days whereas NOB + CIS was applied nobiletin during the first four days of the study. Cisplatin (4 mg/kg, i.p. twice a day) was administered to the experimental groups on the 5th day of the study. All rats were sacrificed on the 10th day of the study. BDNF, NGF, G6PD, GPx, tGSH and MDA levels were determined in brain. In addition, routin histolopathological analysis and caspase-3 immunoreactivity assay were conducted. Results BDNF concentrations increased in nobiletin-administered groups, compared to Control and CIS and that the increase was statistically significant in NOB + CIS (p < 0.05). It was also found that G6PD activity increased (p < 0.05) in the nobiletin-administered groups, compared to control and CIS. Histopathologically, neuronal degeneration, oedema and gliosis increased in CIS compared to Control, and nobiletin administration decreased neuronal degeneration and oedema compared to CIS (p < 0.05). Cisplatin increased (p < 0.05) caspase-3 immunoreactivity in cerebrovascular endothelium and neurons compared to Control, while nobiletin administration decreased caspase-3 immunoreactivity in cerebrovascular endothelium. Caspase-3 immunoreactivity in neurons decreased only in NOB + CIS (p < 0.05). Conclusion Nobiletin increased BDNF concentration and G6PD activity in brain and when evaluated together with histopathological and immunohistochemical findings, it may have antioxidant, antiapoptotic and neuroprotective effects against cisplatin.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Research Fund [18.M.023]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Research Fund (18.M.023).en_US
dc.identifier.doi10.1080/00207454.2021.1896507
dc.identifier.endpage537en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue5en_US
dc.identifier.pmid33650929en_US
dc.identifier.scopus2-s2.0-85105966210en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage531en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2021.1896507
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8097
dc.identifier.volume132en_US
dc.identifier.wosWOS:000626385100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBDNFen_US
dc.subjectcaspase-3en_US
dc.subjectcisplatinen_US
dc.subjectG6PDen_US
dc.subjectnobiletinen_US
dc.titleProtective effects of nobiletin on cisplatin induced neurotoxicity in ratsen_US
dc.typeArticleen_US

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