Effect of mesalamine on healing in experimental colon anastomosis: A randomised experimental study

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dc.authorscopusid57192928442
dc.authorscopusid22958895200
dc.authorscopusid22937913600
dc.authorscopusid35584166600
dc.authorscopusid16242475000
dc.authorscopusid22939717900
dc.authorscopusid23033378900
dc.contributor.authorAslan, Ahmet
dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorPolat, Gurbuz
dc.contributor.authorTumer, Cemil
dc.contributor.authorTemiz, Abdulkerim
dc.contributor.authorCanbolant, Elif
dc.date.accessioned2024-09-19T15:43:29Z
dc.date.available2024-09-19T15:43:29Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n = 8); group II, anastomosis + oral mesalamine group (100 mg/kg/day); group III, anastomosis + rectal mesalamine (2 mL) group, (GIII, n = 8); group IV, anastomosis + oral mesalamine + rectal mesalamine (GIV, n = 8) group. A sham group (n = 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model. © 2007 Surgical Associates Ltd.en_US
dc.identifier.doi10.1016/j.ijsu.2007.09.003
dc.identifier.endpage44en_US
dc.identifier.issn1743-9191
dc.identifier.issue1en_US
dc.identifier.pmid18088577en_US
dc.identifier.scopus2-s2.0-40849097940en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2007.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14349
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnastomosisen_US
dc.subjectBursting pressureen_US
dc.subjectHealingen_US
dc.subjectHydroxyprolineen_US
dc.subjectMesalamineen_US
dc.titleEffect of mesalamine on healing in experimental colon anastomosis: A randomised experimental studyen_US
dc.typeArticleen_US

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