The Effect of Renin-Angiotensin Blockers on COVID-19 Related Mortality: A Tertiary Center's Experience

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dc.authoridUnal, Orcun/0000-0003-1859-8533
dc.contributor.authorOflar, Ersan
dc.contributor.authorKoyuncu, Atilla
dc.contributor.authorAlp, Murat Erdem
dc.contributor.authorKaraosmanogul, Hayat Kumbasar
dc.contributor.authorUnal, Orcun
dc.contributor.authorBeyaz, Metin Onur
dc.contributor.authorOztas, Didem Melis
dc.date.accessioned2024-09-18T19:54:21Z
dc.date.available2024-09-18T19:54:21Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The first reports on coronaviruse disease 2019 (COVID-19) revealed an exaggerated mortality rate in hypertensive patients. In this regard, concerns about angiotensin-converting enzyme (ACE) inhibitors' and angiotensin-receptor blockers' (ARBs) have been aroused. Our aim in this study was to evaluate the potential bad outcome effect of hypertension and anti-hypertensive therapy on COVID-19. Methods: 183 patients with polymerase-chain-reaction (PCR)-proven COVID-19, who were admitted to our hospital and consulted to cardiology department between 15th of March and 15th of April 2020 were inclu-ded. Data were recruited from hospital records. Results: Thirty-two out of 183 patients with COVID-19 died in hospital. Hypertension incidence was not sta-tistically different between patients who survived and died (76 [50.3%] vs 19 [59.4%, p = 0.352]). Although the usage rate of ACEI were similar among groups, ARB usage rate was significantly higher in patients who died than survived (11 [34.4%] vs 23 [15.2%], p = 0.011). Binary regression analysis showed an association between ARBs and mortality (OR: 0.032, 95% CI 1.045-2.623, p = 0.032). Conclusion: Our study confirmed previous concerns regarding a potential harmful effects of ARBs on COVID-19 related mortality.en_US
dc.identifier.doi10.33678/cor.2021.123
dc.identifier.endpage281en_US
dc.identifier.issn0010-8650
dc.identifier.issn1803-7712
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85135095200en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.33678/cor.2021.123
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7688
dc.identifier.volume64en_US
dc.identifier.wosWOS:000826775300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCzech Soc Cardiology & Czech Soc Cardiovascular Surgeryen_US
dc.relation.ispartofCor Et Vasaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiotensin converting enzymeen_US
dc.subjectCOVID-19en_US
dc.subjectPandemicsen_US
dc.subjectRenin-angiotensinen_US
dc.titleThe Effect of Renin-Angiotensin Blockers on COVID-19 Related Mortality: A Tertiary Center's Experienceen_US
dc.typeArticleen_US

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