Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits

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dc.contributor.authorOnlen, Yusuf
dc.contributor.authorTamer, Cengaver
dc.contributor.authorOksuz, Huseyin
dc.contributor.authorDuran, Nizami
dc.contributor.authorAltug, Mehmet Enes
dc.contributor.authorYakan, Selvinaz
dc.date.accessioned2024-09-18T20:55:29Z
dc.date.available2024-09-18T20:55:29Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the current study was to evaluate the effects of five different treatment combinations to find out whether propolis could be an alternative or an adjunctive treatment, in experimental Pseudomonas aeruginosa keratitis. Intrastromal P aeruginosa strains were given to both eyes of 20 young New Zealand white rabbits. The rabbits were randomly divided equally into five treatment groups; ciprofloxacin and dexamethasone drops (C+D), ciprofloxacin drop (C), ciprofloxacin and propolis drops (C+P), propolis drop (P), 3% ethanol drop (control), respectively. Directly before the first treatment and 108h after inoculation, the eyes were examined by slit lamp to assess the corneal opacity and rabbits were sacrificed for bacterial count. The mean corneal opacity scores and the mean bacterial counts log cfu/ml were significantly different in the treatment groups (P = 0.001; ANOVA). According to post hoc tests for both the mean bacterial counts and corneal opacity scores, C+D, C, C+P groups were found to be statistically the same (P > 0.05), and although the P group had significantly better scores than the control group it did not reach the scores of the rest of the treatment groups (P < 0.01). We conclude that propolis may be a useful adjunctive agent but should not be regarded as a replacement for traditional antibiotic therapy for P aeruginosa keratitis in rabbits. (c) 2006 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.micres.2006.07.004
dc.identifier.endpage68en_US
dc.identifier.issn0944-5013
dc.identifier.issue1en_US
dc.identifier.pmid16904302en_US
dc.identifier.scopus2-s2.0-33846063866en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.1016/j.micres.2006.07.004
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11858
dc.identifier.volume162en_US
dc.identifier.wosWOS:000244182200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofMicrobiological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpropolisen_US
dc.subjectexperimental keratitisen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleComparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbitsen_US
dc.typeArticleen_US

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