Association of folic acid receptor ? in maternal serum with neural tube defects

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dc.authoridCelik, Ebru/0000-0002-0774-4294
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authoridOzyalin, Fatma/0000-0001-6486-6389
dc.contributor.authorCelik, Ebru
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorTurhan, Ugur
dc.contributor.authorGungoren, Arif
dc.contributor.authorTaskapan, Cagatay
dc.contributor.authorOzyalin, Fatma
dc.date.accessioned2024-09-18T20:25:10Z
dc.date.available2024-09-18T20:25:10Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs). Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07). Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.en_US
dc.identifier.doi10.3109/14767058.2013.849239
dc.identifier.endpage1087en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue11en_US
dc.identifier.pmid24094304en_US
dc.identifier.scopus2-s2.0-84902989760en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1083en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.849239
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10123
dc.identifier.volume27en_US
dc.identifier.wosWOS:000337901700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFolateen_US
dc.subjectfolic acid receptor alphaen_US
dc.subjectmaternal serumen_US
dc.subjectneural tube defecten_US
dc.titleAssociation of folic acid receptor ? in maternal serum with neural tube defectsen_US
dc.typeArticleen_US

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