ANTIPROLIFERATIVE EFFECTS OF Origanum syriacum L. AND Myrtus communis L. ON HUMAN COLON CANCER CELL LINE

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dc.contributor.authorOzturk, Sevket
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T20:06:25Z
dc.date.available2024-09-18T20:06:25Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description7th International Conference on Advanced Materials and Systems -- OCT 18-20, 2018 -- Bucharest, ROMANIAen_US
dc.description.abstractIn this study, we aimed to investigate the composition and antiproliferative efficacy of Origanum syriacum L. and Myrtus communis L. essential oils on the HCT cell line. Also, it was aimed to search the synergistic activities of Origanum syriacum L. and Myrtus communis essential oils with MTX (Methotrexate) on HCT 116 cells. The main essential oil components of Origanum syriacum L. were Thymol (42,18%), Carvacrol (33,95%), Cymene (8,87%), gamma-Terpinene (8,21%) and for Myrtus communis L. the main essential oil components were Eucalyptol (45,41%), alpha-Pinene (20,86%), Linalool (9,71%). In this study, HCT 116 human colon cancer cell line and Vero cell line were used. To determine the non-cytotoxic concentration of Origanum syriacum L. and Myrtus communis L. essential oils Vero cell line was selected. The cytotoxic activity of the essential oils was measured using the MTT method and the results were evaluated as IC50. The Inhibition concentrations of the essential oils of Origanum syriacum L. and Myrtus communis L. essential oils against cancer HCT 116 and Vero cells were evaluated. It has been found that the essential oils of the Origanum syriacum L. and Myrtus communis have an important antiproliferative effect on human colon cancer cells. In our study findings, we think that these two plant essential oils may be a potent drug active compound for cancer treatment.en_US
dc.description.sponsorshipMinist Res & Innovat,Natl Res & Dev Inst Textile & Leather, Div Leather & Footwear Res Insten_US
dc.identifier.doi10.24264/icams-2018.IV.3
dc.identifier.endpage260en_US
dc.identifier.scopus2-s2.0-85111817652en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://doi.org/10.24264/icams-2018.IV.3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8513
dc.identifier.wosWOS:000464905000040en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIncdtp-Icpien_US
dc.relation.ispartofProceedings of The 7th International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandidaen_US
dc.subjectOriganum syriacum L.en_US
dc.subjectessential oilsen_US
dc.subjectantifungalen_US
dc.subjectresistanceen_US
dc.titleANTIPROLIFERATIVE EFFECTS OF Origanum syriacum L. AND Myrtus communis L. ON HUMAN COLON CANCER CELL LINEen_US
dc.typeConference Objecten_US

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