EFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASE

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dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorGorur, Sadik
dc.contributor.authorMelek, Ismet Murat
dc.contributor.authorOkuyucu, Esra
dc.contributor.authorHelli, Ali
dc.contributor.authorDuman, Taskin
dc.contributor.authorKiper, Ahmet Namik
dc.date.accessioned2024-09-18T20:53:06Z
dc.date.available2024-09-18T20:53:06Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractIntroduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.en_US
dc.identifier.endpage117en_US
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue1en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11577
dc.identifier.volume34en_US
dc.identifier.wosWOS:000420482500018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectBPHen_US
dc.subjectLower Urinary Tract Symptomsen_US
dc.subjectTamsulosinen_US
dc.titleEFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASEen_US
dc.typeArticleen_US

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