Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae

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dc.authoridGul, Alvina/0000-0002-7323-1905
dc.authoridMetin, Mert/0000-0003-3476-1089
dc.authoridKawano, Tomonori/0000-0002-6876-9399
dc.contributor.authorOzturk, Munir
dc.contributor.authorMetin, Mert
dc.contributor.authorAltay, Volkan
dc.contributor.authorDe Filippis, Luigi
dc.contributor.authorUnal, Bengu Turkyilmaz
dc.contributor.authorKhursheed, Anum
dc.contributor.authorGul, Alvina
dc.date.accessioned2024-09-18T20:06:20Z
dc.date.available2024-09-18T20:06:20Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCadmium (Cd) is a toxic heavy metal mainly originating from industrial activities and causes environmental pollution. To better understand its toxicity and pollution remediation, we must understand the effects of Cd on living beings. Saccharomyces cerevisiae (budding yeast) is an eukaryotic unicellular model organism. It has provided much scientific knowledge about cellular and molecular biology in addition to its economic benefits. Effects associated with copper and zinc, sulfur and selenium metabolism, calcium (Ca2+) balance/signaling, and structure of phospholipids as a result of exposure to cadmium have been evaluated. In yeast as a result of cadmium stress, mitogen-activated protein kinase, high osmolarity glycerol, and cell wall integrity pathways have been reported to activate different signaling pathways. In addition, abnormalities and changes in protein structure, ribosomes, cell cycle disruption, and reactive oxygen species (ROS) following cadmium cytotoxicity have also been detailed. Moreover, the key OLE1 gene that encodes for delta-9 FA desaturase in relation to cadmium toxicity has been discussed in more detail. Keeping all these studies in mind, an attempt has been made to evaluate published cellular and molecular toxicity data related to Cd stress, and specifically published on S. cerevisiae.en_US
dc.identifier.doi10.1007/s12011-021-02584-7
dc.identifier.endpage4846en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue12en_US
dc.identifier.pmid33462792en_US
dc.identifier.scopus2-s2.0-85100133387en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4832en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02584-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8467
dc.identifier.volume199en_US
dc.identifier.wosWOS:000608685600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCadmiumen_US
dc.subjectMolecular biologyen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectToxicityen_US
dc.titleMolecular Biology of Cadmium Toxicity in Saccharomyces cerevisiaeen_US
dc.typeArticleen_US

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