Effects of Erdosteine on Acetaminophen-induced Hepatotoxicity in Rats

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dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.contributor.authorKuvandik, Guven
dc.contributor.authorDuru, Mehmet
dc.contributor.authorNacar, Ahmet
dc.contributor.authorYonden, Zafer
dc.contributor.authorHelvaci, Rami
dc.contributor.authorKoc, Ahmet
dc.contributor.authorKozlu, Tolunay
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated the effects of erdosteine on acetaminophen (APAP)-induced hepatotoxicity in rats. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), AST (aspartate aminotransferase), and ALT (alanine transaminase) activities, and malonyldialdehyde (MDA) and nitric oxide levels as oxidant/antioxidant biochemical parameters were investigated with light microscopic evaluation in adult female Wistar Albino rats. APAP administration produced a decrease in hepatic SOD, CAT, and GSH-Px activities, and coadministration of erdosteine (150 and 300 mg/kg) resulted in increases in the activities. MDA and NO levels increased in the APAP group, and erdosteine treatments prevented these increases. Significant elevations in serum AST and ALT levels were observed in the APAP group, and when erdosteine and APAP were coadministered, their serum levels were close to those in the control group. Light microscopic evaluation of livers showed that there were remarkable centrilobular (zone III) hepatic necrosis and mild to moderate sinusoidal congestion in the APAP group, whereas in the erdosteine group, cellular necrosis was minimal and the hepatocytes maintained a better morphology when compared to the APAP group. Erdosteine prevented APAP-induced liver injury and toxic side effects probably through the antioxidant and radical scavenging effects of erdosteine.en_US
dc.identifier.doi10.1177/0192623308320800
dc.identifier.endpage719en_US
dc.identifier.issn0192-6233
dc.identifier.issn1533-1601
dc.identifier.issue5en_US
dc.identifier.pmid18648099en_US
dc.identifier.scopus2-s2.0-49749121480en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.1177/0192623308320800
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7311
dc.identifier.volume36en_US
dc.identifier.wosWOS:000267459500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicologic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetaminophenen_US
dc.subjecterdosteineen_US
dc.subjecthepatotoxicityen_US
dc.subjectfree oxygen speciesen_US
dc.titleEffects of Erdosteine on Acetaminophen-induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

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