Protective effects of tadalafil on experimental spinal cord injury in rats

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dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.authoridGuven, Esref Oguz/0000-0003-4919-9383
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorYonden, Zafer
dc.contributor.authorOzgiray, Erkin
dc.contributor.authorOktar, Sueleyman
dc.contributor.authorGuven, Esref Oguz
dc.contributor.authorSogut, Sadik
dc.contributor.authorYilmaz, Nebi
dc.date.accessioned2024-09-18T19:54:37Z
dc.date.available2024-09-18T19:54:37Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Nitric oxide (NO) functions as a retrograde neurotransmitter in the spinal cord, and postsynaptic structures respond to NO by producing cGMP. The concentrations of cGMP in the spinal cord are controlled by the actions of PDE. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and tadalafil on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T8-10. The 28 rats were randomly divided into four equal groups: tadalafil, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma. At the end of the experiment, blood samples were collected and spinal cord tissue samples were harvested for biochemical evaluation. The tissue level of NO was increased in the tadalafil group compared with the non-treatment and methylprednisolone groups (p < 0.05). The tissue levels of SOD and GSH-Px did not differ between the groups. Serum levels of NO were higher in the tadalafil group than in the non-treatment group (p < 0.05). The increase in serum SOD levels was greater in the tadalafil group than the methylprednisolone group. Serum MDA levels in the tadalafll and methylprednisolone groups tended to be lower than in the non-treatment group (p > 0.05). Tissue MDA levels in the taclalafil and methylprednisolone groups tended to be lower than in the non-treatment group and sham groups (p > 0.05). Although there was no difference in neurological outcome scores between the taclalafil, methylprednisolone and non-treatment groups (p > 0.05), the animals in the taclalafil and methylprednisolone groups tended to have better Scores than the non-treatment group. Thus, tadalafil appears to be beneficial in reducing the effects of injury to the spinal cord by increasing tissue levels of NO and serum activity of SOD. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2009.03.036
dc.identifier.endpage352en_US
dc.identifier.issn0967-5868
dc.identifier.issue3en_US
dc.identifier.pmid19875292en_US
dc.identifier.scopus2-s2.0-75349103535en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2009.03.036
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7828
dc.identifier.volume17en_US
dc.identifier.wosWOS:000274840700019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric oxideen_US
dc.subjectOxidanten_US
dc.subjectPhosphodiesterase type 5en_US
dc.subjectSpinal cord injury, Spineen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectTadalafilen_US
dc.titleProtective effects of tadalafil on experimental spinal cord injury in ratsen_US
dc.typeArticleen_US

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