Effects of dexmedetomidine and tramadol administered before induction of anesthesia on postoperative pain

Basit Öğe Kaydı
dc.authorscopusid24775221500
dc.authorscopusid13613040200
dc.authorscopusid56253149200
dc.authorscopusid58639818100
dc.contributor.authorÖzbakiş Akkurt, B. Ça?la
dc.contributor.authorInano?lu, Kerem
dc.contributor.authorTurhano?lu, Selim
dc.contributor.authorAsfuro?lu, Zeynel
dc.date.accessioned2024-09-19T15:43:29Z
dc.date.available2024-09-19T15:43:29Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Dexmedetomidine is a selective ?2-adrenergic receptor blocker with sedative and analgesic effects. It has been shown to reduce postoperative pain and morphine consumption but its clinical use is limited because of its potential cardiovascular side effects. Tramadol is an opioid analgesic with a similar potency to meperidine. Although it is not as potent as morphine, it is preferred in clinical practice because of its relatively low potential side effects. We aimed to compare the effect and side effects of preoperative dexmedetomidine or tramadol administration on postoperative pain and analgesic consumption. Method: Sixty patients were randomly assigned into three groups to receive lmg kg-1 iv tramadol, or l ?g kg-1 iv dexmedetomidine, or the same volume of saline before induction of anaesthesia. At the time of skin closure, patients were given a standardized bolus dose of morphine and then were allowed to use a patient controlled analgesia (PCA) device. Blood pressures and heart rate were recorded before and after the infusion of the drugs and induction and 1 minute after intubation. Sedation, pain score, cumulative morphine consumption and side effects were recorded 15 minutes, and 2, 6, 12, and 24 hours after initiation of PCA. Results: There were decrease in the blood pressures and heart rates of the patients in the dexmedetomidine group (p<0.05). Postoperative pain and morphine consumption were significantly reduced in the dexmedetomidine group (Group T: 29.87 mg, Group D: 20.95 mg, p<0.05). VAS was lower in the dexmedetomidine group and postoperative sedation scores were higher in the dexmedetomidine group in the first 6 hours. Conclusion: Preoperative dexmetedomidine reduced postoperative morphine consumption more effectively than tramadol without an important adverse effect on hemodynamic parameteres.en_US
dc.identifier.endpage187en_US
dc.identifier.issn1300-0578
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-60149107808en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14346
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectDexmedetomidineen_US
dc.subjectPostoperative painen_US
dc.subjectTramadolen_US
dc.titleEffects of dexmedetomidine and tramadol administered before induction of anesthesia on postoperative painen_US
dc.title.alternativeAnestezi?i?ndüksi?yonu öncesi?uygulanan tramadol veya deksmedetomi?di?n'i?n postoperati?f a?ri üze?ine etki?le?ien_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu