The Matrix Metalloproteinase Inhibitor Batimastat Reduces Epidural Fibrosis After Laminectomy in Rats

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dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorYurtal, Ziya
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.contributor.authorUrfali, Boran
dc.contributor.authorUrfali, Senem
dc.date.accessioned2024-09-18T20:04:20Z
dc.date.available2024-09-18T20:04:20Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: To investigate the efficacy of locally applied batimastat after laminectomy in preventing postoperative epidural fibrosis. MATERIAL and METHODS: Thirty-two Wistar albino male rats weighing 200-250 g were used. The rats were assigned to four different groups (I-Control group, II-sham group, III-Laminectomy+Batimastat group, and IV-Laminectomy+Spongostan (TM) group). The rats were euthanized 28 days after surgery before TNF-alpha, IL6, IL-1 beta, IL10, TGF-beta 1, and MMP9 gene expression levels of tissue in the surgical area were determined with qPCR. TNF-alpha, IL6, and IL10 protein levels were also measured in both tissue and plasma. In addition, the surgical area was evaluated by histopathological and immunohistochemical methods. RESULTS: TNF-alpha, IL6, and IL-1 beta gene expression levels were higher in the batimastat group than in the control group. Whereas IL10 gene expression levels increased about two-fold in the sham and Spongostan (TM) groups, in the batimastat group, it was similar to that in the control group. TGF-beta 1 gene expression was three-fold higher in the sham group but was similar to that in the control group in both batimastat and Spongostan (TM) groups. MMP9 gene expression levels significantly decreased only in the batimastat group. In addition, fibrosis score, fibroblast cell count, inflammatory cell count, and CD105 expression decreased in the batimastat group relative to the control. CONCLUSION: Molecular and pathological examination results suggested that batimastat is an effective agent in reducing the occurrence of epidural fibrosis after laminectomy.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Hatay Mustafa Kemal University [20, 029]; National Institutes of Health Research (NIHR) [029] Funding Source: National Institutes of Health Research (NIHR)en_US
dc.description.sponsorship? ACKNOWLEDGMENT This study was financially supported by the Scientific Research Projects Coordination Unit of Hatay Mustafa Kemal University (Project No. 20.M.029) .en_US
dc.identifier.doi10.5137/1019-5149.JTN.41841-22.2
dc.identifier.endpage170en_US
dc.identifier.issn1019-5149
dc.identifier.issue1en_US
dc.identifier.pmid36482856en_US
dc.identifier.scopus2-s2.0-85147234896en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.41841-22.2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8091
dc.identifier.volume33en_US
dc.identifier.wosWOS:000926119100023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBatimastaten_US
dc.subjectCD105en_US
dc.subjectEpidural fibrosisen_US
dc.subjectPostlaminectomy Syndromeen_US
dc.subjectLaminectomyen_US
dc.titleThe Matrix Metalloproteinase Inhibitor Batimastat Reduces Epidural Fibrosis After Laminectomy in Ratsen_US
dc.typeArticleen_US

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