In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes

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dc.authoridIstifli, Erman Salih/0000-0003-2189-0703
dc.authoridBuyukleyla, Mehmet/0000-0002-4450-2710
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorIstifli, Erman Salih
dc.contributor.authorBuyukleyla, Mehmet
dc.contributor.authorRencuzogullari, Eyyup
dc.contributor.authorTopaktas, Mehmet
dc.date.accessioned2024-09-18T19:47:58Z
dc.date.available2024-09-18T19:47:58Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstract4-Thujanol (sabinene hydrate), a bicyclic monoterpene alcohol, is found in the essential oils of many aromatic and medicinal plants and is widely used as a fragrance and flavouring agent in many different products. The aim of this study was to evaluate the protective effects of 4-thujanol against the genotoxic effects induced by mitomycin C (MMC) and cyclophosphamide (CP) in human lymphocytes, using the chromosome aberrations, sister chromatid exchanges, and micronucleus tests, in the absence and in the presence of S9 mix, respectively. The cells were treated with 0.25 mu g/mL MMC and 28 mu g/mL CP as alone and cotreated with 13 + 0.25, 26 + 0.25, and 52 + 0.25 mu g/mL 4-thujanol + MMC and with 13 + 28, 26 + 28, and 52 + 28 mu g/mL 4-thujanol + CP as a mixture. The present study showed that 4-thujanol was unable to reduce the genetic damage induced by MMC, in the absence of S9 mix. On the other hand, probably the metabolites of 4-thujanol act as an antagonist and markedly antagonize CP-induced genotoxicity, in the presence of S9 mix. In general, 4-thujanol + MMC and 4-thujanol + CP decreased the mitotic index, proliferation index and nuclear division index to the same extent or more than those of individual exposure of MMC or CP. In conclusion, 4-thujanol significantly reduced (p < 0.001) the genotoxic damage induced by CP but not MMC when compared with the respective positive control alone. We can suggest that 4-thujanol may improve the chemopreventive effects and may also reduce the harmful side effects of CP, which is widely used in chemotherapy against cancer, without reducing its anti-proliferative activities.en_US
dc.description.sponsorshipThe Scientific and Technical Research Council of Turkey, Ankara (TUBITAK) [109T546]en_US
dc.description.sponsorshipThis investigation was supported by a grant from The Scientific and Technical Research Council of Turkey, Ankara (TUBITAK, Project No. 109T546).en_US
dc.identifier.doi10.1177/0748233712436640
dc.identifier.endpage37en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue1en_US
dc.identifier.pmid22323477en_US
dc.identifier.scopus2-s2.0-84873860177en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712436640
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7256
dc.identifier.volume29en_US
dc.identifier.wosWOS:000314257600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject4-thujanolen_US
dc.subjecthuman peripheral lymphocytesen_US
dc.subjectantagonistic effecten_US
dc.subjectchromosome aberrationsen_US
dc.subjectsister chromatid exchangesen_US
dc.subjectmicronucleusen_US
dc.subjectmitomycin Cen_US
dc.subjectcyclophosphamideen_US
dc.titleIn vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytesen_US
dc.typeArticleen_US

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