Changes in the cornea related to sickle cell disease: a pilot investigation

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dc.contributor.authorCoskun, Mesut
dc.contributor.authorIlhan, Ozgur
dc.contributor.authorIlhan, Nilufer
dc.contributor.authorTuzcu, Esra Ayhan
dc.contributor.authorDaglioglu, Mutlu Cihan
dc.contributor.authorKahraman, Hilal
dc.contributor.authorElbeyli, Ahmet
dc.date.accessioned2024-09-18T20:08:09Z
dc.date.available2024-09-18T20:08:09Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To investigate corneal structural changes (central corneal thickness, endothelial cell count, and cellular morphology) in patients with sickle cell disease (SCD). Methods: This prospective study included 56 patients with SCD and 50 age- and sex-matched healthy subjects without any eye disease aside from refractive errors. Endothelial cell density (ECD), percentage of hexagonality, and the coefficient of variation in cell size (CV) were measured using noncontact specular microscopy, and central corneal thickness (CCT) was measured by pachymetry. Results: The mean CCT value was 509.6 +/- 20.7 mu m in the study group and 520.8 +/- 23.6 mu m in the control group. The mean ECD, CV, and percentage of hexagonality values in the study group were 2712 +/- 335 cells/mm(2), 34.5 +/- 5.3%, and 57.2 +/- 6.6%, respectively, and 3030 +/- 247 cells/mm(2), 31.6 +/- 5.0%, and 60.4 +/- 6.9% in the control group, respectively. Endothelial cell density (p = 0.001), CCT (p = 0.011), CV (p = 0.005), and percentage of hexagonality values (p = 0.018) were significantly different between the study and control groups. Conclusions: The results of the current study indicate that patients with SCD had considerable morphologic changes in the structure of the cornea when compared to healthy subjects.en_US
dc.identifier.doi10.5301/ejo.5000598
dc.identifier.endpage467en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue6en_US
dc.identifier.pmid25837643en_US
dc.identifier.scopus2-s2.0-84945932287en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage463en_US
dc.identifier.urihttps://doi.org/10.5301/ejo.5000598
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8669
dc.identifier.volume25en_US
dc.identifier.wosWOS:000366484400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Publen_US
dc.relation.ispartofEuropean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral corneal thicknessen_US
dc.subjectCorneal endotheliumen_US
dc.subjectSickle cell diseaseen_US
dc.subjectSpecular microscopyen_US
dc.titleChanges in the cornea related to sickle cell disease: a pilot investigationen_US
dc.typeArticleen_US

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