Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats

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dc.authoridcaglayan, cuneyt/0000-0001-5608-554X
dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridKUCUKLER, Sefa/0000-0002-8222-5515
dc.contributor.authorKuzu, Muslum
dc.contributor.authorYildirim, Serkan
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorKucukler, Sefa
dc.contributor.authorCaglayan, Cuneyt
dc.contributor.authorTurk, Erdinc
dc.contributor.authorDortbudak, Muhammet Bahaeddin
dc.date.accessioned2024-09-18T20:15:22Z
dc.date.available2024-09-18T20:15:22Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlthough Doxorubicin (DOX) is a widespread drug used in the treatment of cancer, its clinical use is restricted due to its common side effects. In addition, administrating DOX with an antioxidant has recently become a new strategy in preventing the side effects of DOX. The protective effects of morin, a natural flavonoid, against DOX-induced liver and kidney damage in rats were investigated biochemically, immunohistochemically and histopathologically in this study. The experimental procedure was planned as 10 days, and 5 groups consisting of seven rats were formed. Morin was given orally to rats at a dose of 50 and 100 mg/kg for 10 days and DOX was given a single dose of 40 mg/kg intraperitoneally on day 8. In order to determine the protective effect of morin against oxidative stress caused by DOX, reduced glutathione (GSH) and malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme activities were measured in liver and kidney tissues. Liver and kidney tissue damage were determined both histopathologically and by serum alanine transaminase (ALT), aspartate transaminase (AST), urea and creatinine analysis. In order to determine the effect of DOX-induced inflammation and against the effect of morin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and nuclear factor kappa B (NF-kappa B) levels were determined in both tissues. Liver and kidney B-cell lymphoma-2 (Bcl-2) levels were determined biochemically. In addition, Bax expression in liver tissue and aquaporin-2 (AQP-2) and nephrin expression in renal tissue were determined immunohistochemically. It was determined that oxidative damage caused by DOX decreased and improvement of liver and kidney function markers were observed in the groups that were treated with morin. In addition, pre-treatment of morin showed a regulatory effect on TNF-alpha, IL-1 beta and NF-kappa B levels. It prevented the increase in DOX-induced Bax expression and decrease in Bcl-2 level, AQP-2 and nephrin expression. Histopathological examination revealed that it prevented tissue damage in liver and kidney tissues.en_US
dc.description.sponsorshipUnit of Scientific Research Projects of University of Agri Ibrahim Cecen [ECZF.17.001]en_US
dc.description.sponsorshipThis research was supported by the Unit of Scientific Research Projects of University of Agri Ibrahim Cecen [Grant number ECZF.17.001].en_US
dc.identifier.doi10.1016/j.cbi.2019.05.017
dc.identifier.endpage100en_US
dc.identifier.issn0009-2797
dc.identifier.issn1872-7786
dc.identifier.pmid31100273en_US
dc.identifier.scopus2-s2.0-85065802500en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2019.05.017
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9586
dc.identifier.volume308en_US
dc.identifier.wosWOS:000474214200009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofChemico-Biological Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectMorinen_US
dc.subjectHepatoprotectiveen_US
dc.subjectNephroprotectiveen_US
dc.titleProtective effect of morin on doxorubicin-induced hepatorenal toxicity in ratsen_US
dc.typeArticleen_US

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